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Leuprolide
Lupron Depot US

Brand names


US: Eligard, Lupron Depot, Lupron Depot-Ped
CAN: Eligard, Lupron, Lupron Depot
INT: Show/Hide

Forms of this drug

Leuprolide (Implant)

Leuprolide (Injectable)

Prescrire drugs to avoid

None

Anticholinergic burden

Score: 0

Beers criteria for older adults

None

Screening tool of older people's prescriptions (STOPP)

None

Black box warning

See product data sheet for complete boxed warning.

None

QT Interval

Possible Risk of TdP

Serotonin syndrome

None

Product data sheet

leuprolide acetate injection, solution  - Packager:

Medication guide

None

Side effects reported

Side effect Reports PRR
Hot flush 2,52240.9
Headache 1,3762.2
Fatigue 1,0171.6
Pain 9281.5
Nausea 8331.0
Arthralgia 7932.2
Death 7591.0
Vaginal haemorrhage 70514.1
Abdominal pain 6882.3
Asthenia 6741.6
Drug ineffective6710.7
Dizziness 6321.1
Weight increased 6312.8
Insomnia 5931.9
Depression 5661.6
Back pain 5362.1
Mood swings 53413.0
Dyspnoea 5130.8
Prostate cancer49722.9
Pain in extremity 4831.5
Injection site pain4711.9
Pelvic pain 44617.5
Menorrhagia 44413.5
Vomiting 4320.8
Fall 4221.1
Endometriosis41783.8
Migraine 4135.0
Night sweats41113.5
Muscle spasms 3882.0
Prostatic specific antigen increased38836.0
Bone pain 3716.0
Feeling abnormal3471.4
Weight decreased 3311.1
Pneumonia 3271.0
Anxiety 3200.8
Myalgia 3171.6
Oedema peripheral 3061.2
Malaise 3020.7
Metrorrhagia 2997.9
Hyperhidrosis 2991.8
Hypoaesthesia 2881.5
Gait disturbance 2841.4
Pyrexia 2840.6
Abdominal distension 2762.5
Prostate cancer metastatic27388.9
Alopecia 2722.3
Off label use2581.4
Decreased appetite 2581.3
Diarrhoea 2490.5
Menstrual disorder24927.1
Memory impairment 2492.0
Anaemia 2470.9
Chest pain2470.9
Metastases to bone 23411.7
Myocardial infarction 2240.6
Muscular weakness 2231.6
Hypertension 2230.8
Paraesthesia 2221.2
Cerebrovascular accident 2180.7
Constipation 2121.1
Haemorrhage 2091.9
Condition aggravated2051.0
Amnesia 2002.2
Rash 1980.5
Mood altered 1956.5
General physical health deterioration1941.6
Urinary tract infection 1891.1
Crying 1833.3
Injection site erythema 1821.3
Vision blurred 1811.2
Uterine leiomyoma17913.9
Blood pressure increased1791.1
Confusional state 1780.9
Injection site swelling 1722.4
Abdominal pain upper 1690.8
Interstitial lung disease 1692.8
Irritability 1672.1
Pruritus 1610.5
Renal failure 1540.8
Mobility decreased 1532.4
Dysuria 1523.1
Hospitalisation 1492.8
Dysmenorrhoea 14812.1
Palpitations 1411.0
Unevaluable event1401.7
Menstruation irregular 1392.9
Thrombosis 1381.3
Urticaria 1300.7
Acne 1304.2
Pulmonary embolism 1270.7
Emotional disorder 1263.4
Chills 1250.9
Cardiac failure 1251.3
Loss of consciousness 1230.7
Ovarian cyst1196.7
Syncope 1190.9
Hysterectomy11910.3
Joint swelling1171.2
Musculoskeletal pain 1161.6
Injection site induration1167.1