RxISK Research on PSSD

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July 18, 2014 | 28 Comments

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  1. Excellent news. This is a great opportunity for the PSSD community to find a scientific basis for the condition and possibly the first steps to finding a successful treatment.

    Is there specific contact method or email address through which PSSD patients can direct their questions or offer their participation?

  2. Great news. have already submitted my symptoms and personal profile via yellow card and on RXISK, I would very much like to be apart of the research.

  3. I’m praying for you find an answer, Dr. Healy. Ι am suicidal every day,every minute. PSSD , emotional blunting and anhedonia (very often relative) is HELL!
    I believe that genital anesthisia (the most characteristic and valid symptom of this terrifying condition) is the worst symptom by any other from all diseases.
    You are ours biggest hope.

    Damn SSRI…

  4. Have there been any thoughts about testing Fenclonine (PCPA) in the treatment of PSSD? It depletes serotonin and has had a fair amount of research into its sexual effects, which include hypersexuality. It looks like it can cause (or at least exacerbate) migraine headaches, as well as depression, but it’s at least theoretically possible that it could cause a permanent reversal of the symptoms of PSSD (e.g. via resensitization of serotonin receptors in the brain).

    Looking around, there hasn’t been much in the way of testing this with patients suffering sexual dysfunction from SSRIs, probably because a lot of the existing research is on patients *currently* taking an SSRI, and Fenclonine would probably eliminate the antidepressant effects of the SSRI. However, for patients who’ve already terminated their SSRI (and are no longer depressed), that might not matter as much.

  5. As a victim of SSRI destruction, one thing I don’t understand is the amount of time these drugs take to have an effect. If I think of other brain affecting drugs, caffeine, nicotine, alcohol, LSD, cocaine, amphetamine, cannabis, or whatever, surely, they enter the bloodstream, cross the blood brain barrier, react with one’s own brain chemistry and bingo you have the effect; followed by one or a few days for your brain to self regulate back to normality. (Obviously long term use of such drugs can have a far more damaging effect). What the hell is going on with SSRIs? You take them, they enter the bloodstream, cross the blood brain barrier and then what? What is happening in all those weeks before the drug takes full effect? Surely the only thing that can be happening is some physiological change in the brain in reaction to the presence of the drug? Now if that is the case, can one expect such a change to reverse back to its pre-drug state once the drug is withdrawn??? Or would it be more reasonable to hypothesize that the brain has been permanently changed and that is why, once one has taken SSRIs, one is destroyed forever? Serotonin function burned out, unable to feel attraction, desire, lust, goal direction and ambition, or even love. Leave someone like that and they are pretty much permanently screwed in every aspect of life. Taking a drug and observing or experiencing its effects are one thing. Stopping a drug is another thing entirely and you never know what a drug has really done until you try living without it and compare how you are then to how you were before you ever took the the brain damaging, life wrecking, soul destroying poison in the first place.

  6. David Healy Rocks!!!!!! Thank you doctor Healy. Maybe I can contribute with my empirical and my self treatment that healed me.
    PS: I had the worst type of post ssri sexual dysfunction. I could not had even a single erection for almost 8 months and now after 3 years of this nightmare I’m doing very good!!!! I’m doing a lot of sex again. I want to help the others guys and girls.

  7. Hello Augusto, please specify in your testimony whether or not you had low testosterone and / or high prolactin, and if you’ve taken care of these hormonal imbalances to heal from PSSD. because would it be different for PSSD suffers that have no hormonal imbalances. sorry for this english.

    • I took a lot of things and I do not think that the testosterone was the problem, at least in my case. My theory is that it is a problem in the cyp (cytochrome P450), mainly in the cyp2d6 and cyp3a4 and some people will need to “fix the cyp” enzymes. One very good thing for it is desmodium(burbur), MSM and Zeolite.

  8. I have had PSSD since I stopped taking citalopram in July 2014. If I had read the Wikipedia article about citalopram prior to taking the drug, I would never have taken it!! I hate the doctor who prescribed me it. I have tried taking licorice root – I found posts online claiming this can eliminate PSSD, but I have yet to see any benefits. I also had a testosterone test, and it came back normal. I do not want to have PSSD for the rest of my life. Sometimes I feel suicidal, but I have to stay positive. I hope a cure will be found or that I will get back to normal through time. Any other ideas of potential benefits?

    • Meg
      The first step is to file a RxISK report. The ideal next step is to take it to your doctor and let us know how s/he responds – whether she listens or not. If she is open to the drug causing the problem having her work with you and us would be great. We will put you on our database and be in touch to let you know more soon.
      David

  9. I have the PSSD. I stopped taking Cymbalta in December 2014, but i feel genital anesthisia and ejaculatory anedonia. I’m afraid that i will have PSSD for the rest of my life. I’m desperate.

  10. It seems to me that a lot of PSSD patients will end up taking the urologist route in their search for a cure. It would be useful if urologists were made aware of the PSSD issue. The urologist contact point would be a useful place for the collection of some data, i.e. the numbers complaining of a particular set of symptoms who have previous SSRI exposure. Urologists do seem to be starting to enter the “low testosterone market” and are therefore picking up more and more sexual dysfunction patients, where the cause is not just a simple case of ED. Unfortunately the expensive, private urologist I consulted didn’t even know what DHEA was, had never heard the expression “free androgen index” and spent more time focusing on my total testosterone result than my free testosterone result. If urologists are to capture this market, I think they need to brush up on their endocrinology first!

  11. PSSD is the most soul-destroying condition to have. I think I will have it for the rest of my life. I have no libido, and I am unable to have sex at all. I have had PSSD for over a year now. It was Citalopram which caused my PSSD.

    • Hey Scott
      Are you better now ? Did you try any solutions maybe things like licorice root , cyproheptadine , maybe going back on some SSRI ?
      Somethings gotta work. Just give yourself enough shots at curing yourself

  12. I have Post ssri sexual dysfunction for over 3 years after I stopped medications.
    I was on Zyprexa and Solbem for 3 years.
    I need help…

  13. PSSD is permanent. Simple as. It’s PPSSD and somehow I am supposed to live with that. Forever. Thanks Doc. There’s nothing you can do about it. I have tried everything and nothing. The feeling never returns. And looking back, those poisonous SSRIs did their damage, or at least started their damage, so very early on. Life gone, life taken, thanks Doc, I will never trust you on anything ever again.

  14. 21 years old, suffering PSSD I stopped Paroxetine 2 years ago. I was on Paroxetine for 8 month. Think about suicide… no love no life. 🙁

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