Medically reviewed by Dr. David Healy on 9 January 2024. What is PSSD? Post-SSRI sexual dysfunction (PSSD) is an iatrogenic condition in which sexual function does not return to normal after the discontinuation of serotonin reuptake inhibiting antidepressants. This group includes: Most people who take an SSRI, SNRI, or related medication, will feel some degree … Continue reading Post-SSRI Sexual Dysfunction (PSSD)