RxISK

Making Medicines Safer for All of Us

Drug Search by Year (Detail)

Side effect search by year (detail)

Drug:

Reaction: ILLNESS

20250101 - 20251231

No. 1 - 100

Next page: 2 next page>>
No.
safetyreportid
occurcountry
patientonsetage
patientsex 1:M 2:F
Adverse reaction
Drug (openfda.generic_name, medicinalproduct)
1
25491692
US
 67 2
Intervertebral disc protrusion, Osteoarthritis, Muscle spasms, Back pain, Illness, Limb discomfort, Nerve oedema,
ADALIMUMAB, ADALIMUMAB,
2
25491731
US
 55 1
Hospitalisation, Skin disorder, Illness,
RISANKIZUMAB-RZAA,
3
25491895
US
 47 2
Illness, Asthma, Product use in unapproved indication,
DUPILUMAB, DUPILUMAB,
4
25491911
US
 64 2
Osteopenia, Mouth ulceration, Illness, Herpes zoster,
SARILUMAB, ATENOLOL, METHOTREXATE, METHOTREXATE SODIUM,
5
25492016
US
Illness,
TIRZEPATIDE,
6
25492040
US
 44 1
Illness, Pneumonia, Pulmonary thrombosis, Sickle cell anaemia with crisis,
LENALIDOMIDE, FOLIC ACID, METOPROLOL SUCCINATE, METOPROLOL SUCCINATE ER TABLETS, OXYCODONE HYDROCHLORIDE, OXYCODONE,
7
25492119
US
 2
Illness,
BELIMUMAB,
8
25492370
US
 58 2
Illness,
TIRZEPATIDE, TIRZEPATIDE, TIRZEPATIDE, TIRZEPATIDE, DRONEDARONE, EXEMESTANE, METHIMAZOLE, METOPROLOL TARTRATE, METOPROLOL, MONTELUKAST,
9
25492635
US
 75 2
Illness, Asthenia, Drug intolerance,
LENALIDOMIDE,
10
25492676
ES
Diarrhoea, Illness, Pain, Decreased immune responsiveness, Blood cholesterol increased, Alopecia, Fatigue,
LOPERAMIDE HYDROCHLORIDE, LOPERAMIDE HCL, ABEMACICLIB, ABEMACICLIB, EXEMESTANE, GOSERELIN,
11
25492747
US
 2
Kidney infection, Device infusion issue, Somnolence, Inappropriate schedule of product administration, Memory impairment, Muscular weakness, Oropharyngeal pain, Infusion site mass, Migraine, Hypersensitivity, COVID-19, Illness, Wrong technique in product usage process, Abdominal discomfort, Malaise, Fatigue,
12
25493013
US
 2
Herpes zoster meningoencephalitis, Meningitis viral, Illness,
NALTREXONE HYDROCHLORIDE AND BUPROPION HYDROCHLORIDE,
13
25493188
ES
Large intestinal ulcer, Feeling abnormal, Illness, Flatulence, Discomfort, Abdominal pain, Malaise, Cognitive disorder, Nervousness, Weight increased, Swelling, Anxiety, Sleep disorder due to general medical condition, insomnia type, Breast inflammation, Functional gastrointestinal disorder, Dyschezia, Tumour marker increased, Memory impairment, Parosmia, Taste disorder, Abdominal pain upper, Dyspepsia, Diarrhoea, Diarrhoea, Fatigue, Nausea, Decreased appetite,
LOPERAMIDE HYDROCHLORIDE, LOPERAMIDE HCL, ABEMACICLIB, ABEMACICLIB, ABEMACICLIB, ABEMACICLIB, ABEMACICLIB, LETROZOLE, LETROZOLE TABLETS,
14
25493527
CA
 65 2
Chills, Illness, Headache, Pain, Pyrexia,
ZOLEDRONIC ACID,
15
25493739
US
Illness, Abdominal pain upper,
TIRZEPATIDE, TIRZEPATIDE, TIRZEPATIDE, TIRZEPATIDE, TIRZEPATIDE,
16
25493774
US
 2
Cerebrovascular accident, Illness, Product colour issue, Injection site pain,
VEDOLIZUMAB, VEDOLIZUMAB, VEDOLIZUMAB, VEDOLIZUMAB,
17
25494030
US
 1
Product use issue, Illness, Weight increased, Depressed mood, Abdominal discomfort, Sinus disorder, Respiratory disorder, Rash pruritic, Malaise, Headache, Fatigue, Sinus congestion,
ACETAMINOPHEN, ACETAMINOPHEN ORAL SOLUTION, ACETAMINOPHEN 500MG, ACETAMINOPHEN TABLET EXTENDED RELEASE, PAIN RELIEVER, EPINEPHRINE, ADRENALINUM, FEXOFENADINE HYDROCHLORIDE, DICLOFENAC POTASSIUM, DICLOFENAC POTASSIUM, FILM COATED, DICLOFENAC POTASSIUM TABLETS, FLUOXETINE HYDROCHLORIDE, TIZANIDINE HYDROCHLORIDE, FLUTICASONE FUROATE AND VILANTEROL TRIFENATATE, SULFASALAZINE, HYDROXYCHLOROQUINE SULFATE, LIDOCAINE, LIDOCAINE HYDROCHLORIDE, BURN RELIEF, MAXIMUM STRENGTH PAIN RELIEVER, LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE, LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE, LIDOCAINE 4%, LIDOCAINE, MENTHOL, LEVALBUTEROL TARTRATE, NALTREXONE HYDROCHLORIDE, METHOTREXATE, METHOTREXATE SODIUM, MONTELUKAST SODIUM, MONTELUKAST, DIPHENHYDRAMINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE CAPSULE, LIQUID FILLED, MAGNESIUM CHLORIDE, GUAIFENESIN,
18
25494057
US
 83 2
Illness,
RIOCIGUAT, RIOCIGUAT, AMBRISENTAN,
19
25494181
US
 34 1
Impaired work ability, Illness, Loss of personal independence in daily activities,
PHENELZINE SULFATE,
20
25494197
US
 64 2
Illness,
TOFACITINIB, GABAPENTIN, DULOXETINE HYDROCHLORIDE, DULOXETINE, ALENDRONATE SODIUM, ALENDRONATE SODIUM TABLET, LEVOTHYROXINE, ALBUTEROL SULFATE, ALBUTEROL,
21
25494637
US
 2
Cerebrovascular accident, Seizure, Gastric operation, Central nervous system lesion, Ulcer, Arthralgia, Illness, Impaired work ability, Skin disorder,
BELIMUMAB,
22
25494969
US
 2
Illness,
LEVONORGESTREL, ETANERCEPT,
23
25495225
US
 35 2
Illness,
TOFACITINIB,
24
25495401
US
 2
Maternal exposure during pregnancy, Illness,
DIMETHYL FUMARATE, DIMETHYL FUMARATE, DIMETHYL FUMARATE, DIMETHYL FUMARATE,
25
25495414
32 2
Cystitis interstitial, Condition aggravated, Illness,
DEXTROMETHORPHAN HYDROBROMIDE, BUPROPION HYDROCHLORIDE,
26
25495577
US
 1
Illness, Drug ineffective,
DUPILUMAB, ACETAMINOPHEN, ACETAMINOPHEN ORAL SOLUTION, ACETAMINOPHEN 500MG, ACETAMINOPHEN TABLET EXTENDED RELEASE, PAIN RELIEVER, OMEPRAZOLE, OMEPRAZOLE MAGNESIUM, DICLOFENAC SODIUM, DICLOFENAC SODIUM TOPICAL, DICLOFENAC SODIUM TOPICAL GEL, 1%, DICLOFENAC, DICLOFENAC SODIUM 1%, CITALOPRAM, CITALOPRAM HYDROBROMIDE, HYDROCHLOROTHIAZIDE,
27
25495760
US
 81 1
Pruritus, Dry skin, Illness, Inappropriate schedule of product administration,
DUPILUMAB,
28
25495824
US
 69 2
Illness, Wrist surgery,
DUPILUMAB, DUPILUMAB,
29
25495950
US
 34 1
Illness, Asthma,
DUPILUMAB, DUPILUMAB,
30
25495979
AR
 51 2
Asthmatic crisis, Rash, Injection site pain, Fear of injection, Illness, Food allergy,
MEPOLIZUMAB, MEPOLIZUMAB,
31
25495981
US
 2
Drug ineffective, Illness, Product odour abnormal, Sinus disorder, Gastritis, Intestinal metaplasia, Feeling abnormal, Chromaturia, Renal pain,
LISDEXAMFETAMINE DIMESYLATE,
32
25499800
39 2
COVID-19, General physical health deterioration, Suicidal ideation, Failure to thrive, Fatigue, Malaise, Dysphagia, Decreased appetite, Weight decreased, Dry mouth, Dysphonia, Anxiety, Heart rate increased, Insomnia, Malnutrition, Illness, Withdrawal syndrome, Panic attack,
CALCIUM, MAGNESIUM, POTASSIUM, AND SODIUM OXYBATES, SERTRALINE, METHYLPHENIDATE, METHYLPHENIDATE HYDROCHLORIDE,
33
25491042
US
 2
Illness, Product dose omission issue,
DUPILUMAB, THIAMINE HYDROCHLORIDE, ERGOCALCIFEROL, CARIPRAZINE,
34
25491051
US
Illness,
INSULIN GLARGINE,
35
25491054
US
 26 2
Illness, Blood immunoglobulin E abnormal,
DUPILUMAB,
36
25491059
US
 59 2
Dizziness, Abdominal discomfort, Lethargy, Illness,
OMEPRAZOLE, OMEPRAZOLE MAGNESIUM,
37
25491101
US
 2
Illness, Dermatitis atopic,
DUPILUMAB,
38
25491181
US
 28 2
Illness, Product dose omission issue,
DUPILUMAB,
39
25491239
US
 3 2
Illness, Rebound eczema,
DUPILUMAB,
40
25491337
US
 73 1
Illness,
DUPILUMAB,
41
25491377
CA
 55 2
Rash, Decreased activity, Dysstasia, Gait disturbance, General physical health deterioration, Grip strength decreased, Illness, Inappropriate schedule of product administration, Influenza, Pain, Psoriatic arthropathy, Treatment failure, Condition aggravated,
METHOTREXATE, METHOTREXATE SODIUM, ADALIMUMAB, ADALIMUMAB-FKJP, ADALIMUMAB-AATY, ADALIMUMAB-ADAZ, CELECOXIB, HYDROCORTISONE, DESOXIMETASONE, ADALIMUMAB, HYDROXYCHLOROQUINE, INFLIXIMAB, MELOXICAM, MELOXICAM, NAPROXEN, NAPROXEN SODIUM, HYDROXYCHLOROQUINE SULFATE, TRAMADOL HYDROCHLORIDE, PREDNISONE, INFLIXIMAB, SULFASALAZINE, ADALIMUMAB-ADAZ,
42
25491417
US
 2
Illness,
43
25489984
US
 2
Illness,
CILTACABTAGENE AUTOLEUCEL,
44
25490042
US
 51 2
Rash macular, Illness, Stress, Neurodermatitis, Arthralgia,
DUPILUMAB,
45
25490076
CA
 59 2
Cardiac failure congestive, Arthralgia, International normalised ratio increased, Stress, Upper gastrointestinal haemorrhage, Illness, Pain, Drug intolerance, Platelet count decreased, Haemorrhage,
METHOTREXATE, METHOTREXATE SODIUM, ETANERCEPT, ETANERCEPT,
46
25490174
US
 33 2
Hepatic enzyme increased, Blood glucose increased, Hypertension, Nausea, Sleep disorder, Weight decreased, Abdominal pain upper, Illness, Feeding disorder,
ROMOSOZUMAB-AQQG,
47
25490272
US
Illness, Cough,
VIGABATRIN,
48
25490279
US
 1
Illness, Cough, Pyrexia,
VIGABATRIN,
49
25490300
AU
 7 2
Viral infection, Illness,
DENOSUMAB, USTEKINUMAB,
50
25490875
US
 40 1
Illness,
51
25486522
US
 71 2
Device difficult to use, Product administration error, Wrong technique in product usage process, Illness, Blood cholesterol decreased,
EVOLOCUMAB, EVOLOCUMAB, ADALIMUMAB,
52
25486587
US
 85 1
Illness, Decreased appetite, Weight decreased,
LENALIDOMIDE,
53
25486791
US
 55 2
Illness,
TIRZEPATIDE, TIRZEPATIDE, TIRZEPATIDE, TIRZEPATIDE, TIRZEPATIDE, GLIMEPIRIDE,
54
25486807
US
 1
Illness,
PIMAVANSERIN TARTRATE,
55
25486951
CA
Condition aggravated, COVID-19, Influenza, Illness, Immune system disorder, Sinusitis,
INFLIXIMAB-DYYB, INFLIXIMAB-DYYB, INFLIXIMAB-DYYB, INFLIXIMAB-DYYB, INFLIXIMAB-DYYB, INFLIXIMAB-DYYB, INFLIXIMAB-DYYB, INFLIXIMAB-DYYB, INFLIXIMAB-DYYB, INFLIXIMAB-DYYB, INFLIXIMAB-DYYB, CELECOXIB, DEXLANSOPRAZOLE, METHOTREXATE, METHOTREXATE SODIUM, METHOTREXATE, METHOTREXATE SODIUM,
56
25487144
US
Illness,
DULAGLUTIDE,
57
25487398
US
 75 2
Feeling abnormal, Illness, Pain, Asthenia, Gait disturbance, Abdominal discomfort, Hypersomnia, Vomiting,
DONANEMAB-AZBT, DONANEMAB-AZBT, DONANEMAB-AZBT, DONANEMAB-AZBT, MEMANTINE, MEMANTINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE,
58
25487581
CO
 1
Death, Illness, Intentional dose omission, Therapy interrupted, Insurance issue, Malaise, Injection site mass, Injection site pain,
LEUPROLIDE ACETATE, LEUPROLIDE ACETATE, LEUPROLIDE ACETATE, CALCIUM,
59
25487602
US
 1
Illness,
RIVASTIGMINE, SACUBITRIL AND VALSARTAN,
60
25488013
DE
 46 2
Myocarditis, Hypoacusis, Tonsillitis, Illness, Urticaria papular, Dyspnoea, Rhinorrhoea, Arthralgia, Muscle spasms, Myalgia, Infection,
DENOSUMAB,
61
25488139
US
 2
Illness,
TREPROSTINIL, TREPROSTINIL, HYDROXYCHLOROQUINE SULFATE, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL HYDROCHLORIDE, SULFAMETHOXAZOLE AND TRIMETHOPRIM, FOLIC ACID, MELATONIN, SODIUM CHLORIDE, SODIUM CHLORIDE INJECTION, SODIUM CHLORIDE TABLET, BACLOFEN, TADALAFIL, KETAMINE HYDROCHLORIDE, ENOXAPARIN SODIUM, DICLOFENAC SODIUM, DICLOFENAC SODIUM TOPICAL, DICLOFENAC SODIUM TOPICAL GEL, 1%, DICLOFENAC, DICLOFENAC SODIUM 1%, BIOTIN, FLUTICASONE PROPIONATE, CLONIDINE, KETOPROFEN, ASPIRIN, ASPIRIN 81 MG, ASPIRIN 325 MG, LIDOCAINE HYDROCHLORIDE, LIDOCAINE HYDROCHLORIDE ANHYDROUS, ACETAMINOPHEN, ACETAMINOPHEN ORAL SOLUTION, ACETAMINOPHEN 500MG, ACETAMINOPHEN TABLET EXTENDED RELEASE, PAIN RELIEVER, MYCOPHENOLIC ACID, MYCOPHENILIC ACID, GABAPENTIN, AMBRISENTAN, ONDANSETRON HYDROCHLORIDE, AZITHROMYCIN, AZITHROMYCIN MONOHYDRATE, AZITHROMYCIN DIHYDRATE, LEVOCETIRIZINE DIHYDROCHLORIDE,
62
25488316
GB
 2
Illness,
TIRZEPATIDE,
63
25488321
US
 1
Illness,
INSULIN GLARGINE,
64
25488330
US
Illness,
TIRZEPATIDE,
65
25488360
US
Illness,
TIRZEPATIDE,
66
25488363
US
 76 2
Illness, Feeding disorder, Malaise, Lethargy, Asthenia,
TIRZEPATIDE, TIRZEPATIDE,
67
25488635
US
 61 2
Illness,
TOFACITINIB,
68
25488691
US
 61 2
Pneumonia, Intervertebral disc protrusion, Infusion related reaction, Nasopharyngitis, Ear infection, Product preparation error, Illness, Gastroenteritis viral, Hypoglycaemia, Pain, White blood cell count decreased, Back pain, Chills, Headache, Brain fog, Malaise, Pyrexia,
HUMAN IMMUNOGLOBULIN G, HUMAN IMMUNOGLOBULIN G, HUMAN IMMUNOGLOBULIN G,
69
25488700
US
 64 2
Illness,
TOFACITINIB,
70
25489167
US
 2
Illness,
SARILUMAB,
71
25489199
US
 29 2
Oropharyngeal pain, Illness,
DUPILUMAB,
72
25489414
US
 65 2
Respiratory tract congestion, Secretion discharge, Illness, Nasopharyngitis, Drug ineffective,
DUPILUMAB,
73
25489852
US
Illness, Drug ineffective,
ESOMEPRAZOLE MAGNESIUM,
74
25490395
GB
 70 1
Illness,
INSULIN HUMAN, ESOMEPRAZOLE, ESOMEPRAZOLE MAGNESIUM, HYDROCORTISONE, ANTIPRURITIC (ANTI-ITCH), ANTI-ITCH CREAM, HYDROCORTISONE 1%, HYDROCORTISONE CONTINUOUS SPRAY, ANTI-PRURITIC, HYDROCORTISONE LOTION, HYDROCORTISONE ACETATE, HYDROCORTISONE LOTION KIT, ANTI ITCH, ANTI-ITCH, COOL RELIEF GEL WITH ALOE, HYDROCORTISONE CREAM 1%, HYDROCORTISONE SPRAY, DRS. HYDROCORTISONE, METFORMIN, METFORMIN ER 500 MG, METFORMIN ER 750 MG, EZETIMIBE, OMEPRAZOLE, OMEPRAZOLE MAGNESIUM, RAMIPRIL,
75
25490445
US
Death, Illness,
AXATILIMAB-CSFR,
76
25490515
US
 44 2
Illness,
LUTETIUM LU 177 DOTATATE,
77
25490697
GB
 52
Medication error, Illness,
METHOTREXATE, METHOTREXATE SODIUM, METHOTREXATE, METHOTREXATE SODIUM,
78
25490705
US
 79 1
Near death experience, Contraindicated product prescribed, Illness, Documented hypersensitivity to administered product,
ACETAMINOPHEN AND CODEINE,
79
25490721
US
 2
Illness, Confusional state, Fear, Device power source issue,
TREPROSTINIL, TREPROSTINIL, ASPIRIN, ALBUTEROL SULFATE, OXYGEN, 0XYGEN, AMIODARONE HYDROCHLORIDE, TORSEMIDE,
80
25490830
US
Abdominal pain upper, Decreased appetite, Illness,
ACORAMIDIS HYDROCHLORIDE,
81
25493780
65 2
Neck pain, Headache, Vomiting, Illness, Nausea, Dizziness, Taste disorder, Dysgeusia,
DENOSUMAB, LEVOTHYROXINE, ROSUVASTATIN, ERGOCALCIFEROL, CALCIUM, HYDROCORTISONE,
82
25481180
US
 2
Feeding disorder, Illness,
ELUXADOLINE,
83
25481245
US
 48 1
Illness, Product dose omission issue,
AVAPRITINIB,
84
25481283
US
 2
Myocardial infarction, Illness, Asthma, Nasopharyngitis, Hyperhidrosis, Platelet count increased, Nausea,
EMPAGLIFLOZIN, EMPAGLIFLOZIN, OMALIZUMAB, FERROUS SULFATE, SEMAGLUTIDE, DULOXETINE HYDROCHLORIDE, DULOXETINE, ALBUTEROL SULFATE, ALBUTEROL, HYDROXYUREA, ROPINIROLE, NITROGLYCERIN, EPINEPHRINE, LEVOTHYROXINE, SPIRONOLACTONE, ASPIRIN, ASPIRIN 81 MG, ASPIRIN 325 MG, METOPROLOL SUCCINATE, METOPROLOL SUCCINATE ER TABLETS, OMEPRAZOLE, OMEPRAZOLE MAGNESIUM, GABAPENTIN, BUDESONIDE AND FORMOTEROL FUMARATE DIHYDRATE, ERGOCALCIFEROL, DICLOFENAC SODIUM,
85
25481326
US
 2
Illness, Incorrect dose administered,
FLUTICASONE FUROATE, UMECLIDINIUM BROMIDE AND VILANTEROL TRIFENATATE,
86
25481463
CA
 2
Root canal infection, Tooth abscess, Facial pain, Neck pain, COVID-19, Gastroenteritis, Illness,
UPADACITINIB,
87
25481479
US
 2
Rheumatoid arthritis, Illness, Maternal exposure during pregnancy, Maternal exposure during breast feeding, Needle issue, Drug ineffective,
CERTOLIZUMAB PEGOL, ERGOCALCIFEROL, FISH OIL, MAGNESIUM, ASPIRIN, ASPIRIN 81 MG, ASPIRIN 325 MG, OMEPRAZOLE, OMEPRAZOLE MAGNESIUM, SERTRALINE HYDROCHLORIDE, ENOXAPARIN SODIUM, HYDROXYCHLOROQUINE SULFATE,
88
25481599
US
 2
Age-related macular degeneration, Pneumonia, Compression fracture, Benign renal neoplasm, Syncope, Illness, Limb injury, Gastrointestinal disorder, Blood glucose increased, Product storage error,
INSULIN DEGLUDEC, SEMAGLUTIDE,
89
25481707
US
 1
Illness,
DOSTARLIMAB,
90
25481752
US
 2
Illness, Product dose omission issue,
TROFINETIDE,
91
25481916
US
 44 1
Asthenia, Dizziness, Illness, Off label use,
LENALIDOMIDE,
92
25482001
DE
 1
Death, Illness, Adverse event,
FINASTERIDE,
93
25482041
CA
Illness, Poisoning, Fear of death,
94
25482078
BR
 79 2
Onychomycosis, Nail discomfort, Psoriasis, Urinary tract infection, Immunodeficiency, Fall, Upper limb fracture, Osteoporosis, Vitiligo, Psoriatic arthropathy, Back pain, Drug hypersensitivity, Illness, Skin exfoliation,
ADALIMUMAB,
95
25482090
US
 55 1
Intestinal resection, Illness,
RISANKIZUMAB-RZAA, RISANKIZUMAB-RZAA, RISANKIZUMAB-RZAA, RISANKIZUMAB-RZAA, RISANKIZUMAB-RZAA, RISANKIZUMAB-RZAA,
96
25482115
US
Surgery, Illness,
SEMAGLUTIDE, SEMAGLUTIDE,
97
25482220
CA
 37 2
Illness, Influenza, Ear infection, Pneumonia,
ETANERCEPT, NAPROXEN SODIUM, NAPROXEN SODIUM 220MG, NAPROXEN SODIUM, COATED TABLETS, NAPROXEN SODIUM TABLET, COATED,
98
25482320
CL
 8 1
Asphyxia, Illness, Productive cough, Discouragement, Irritability, Restlessness, Respiratory tract congestion, Lacrimation increased, Cough, Dyspnoea, Pyrexia, Vomiting,
IDURSULFASE, IDURSULFASE, IDURSULFASE,
99
25482348
US
 2
Disability, Drug ineffective, Illness, Mental disorder, Injury, Gait disturbance,
UPADACITINIB,
100
25482453
US
 2
Visual impairment, Illness,
MEPOLIZUMAB,

disclaimer

Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.

terms

https://open.fda.gov/terms/

license

https://open.fda.gov/license/

last_updated

2025-07-29

Next page: 2 next page>>