Below is a list of all relevant academic literature involving post-SSRI sexual dysfunction (PSSD). It includes studies, review articles, editorials and commentaries.
We have also included a small number of theses/dissertations that make an important contribution to the knowledge base.
Articles marked “open access” are available in full.
Medical textbooks are excluded as they do not typically undergo the same peer-review process as journal articles and are generally regarded as less authoritative. They also usually repeat information that is already in the literature.
Articles that mention PSSD but are not substantially about the condition are also excluded.
2025
Paroxetine-induced dopamine dysregulation: Insights into the pathogenesis of post-SSRI sexual dysfunction (PSSD)
Giatti S, Chrostek G, Cioffi L, Diviccaro S, Sanna F, Melcangi RC
The Journal of Sexual Medicine
Open access
Understanding the Experiences of People with Post-SSRI Sexual Dysfunction
Rice EE, Kleinplatz PJ, Richardson HM, DiCaita H, D’souza K, Charest M, Rosen L
Journal of Sex & Marital Therapy
Insights into the peripheral nature of persistent sexual dysfunction associated with post-finasteride, post-SSRI and post-accutane syndromes: lessons learned from a case study
Stachelek J, Zwaans BMM, Shtein R, Peters KM
International Urology and Nephrology
2024
Psychological and sexual functioning of persons suffering from post-SSRI sexual dysfunction – cases study
Gargul K, Pastwa-Wojciechowska B
Current Issues in Personality Psychology
Open access
Frequency of self-reported persistent post-treatment genital hypoesthesia among past antidepressant users: a cross-sectional survey of sexual and gender minority youth in Canada and the US
Pirani Y, Delgado-Ron JA, Marinho P, Gupta A, Grey E, Watt S, MacKinnon KR, Salway T
Social Psychiatry and Psychiatric Epidemiology
Post-SSRI sexual dysfunction: barriers to quantifying incidence and prevalence
Healy D, Mangin D
Epidemiology and Psychiatric Sciences
Open access
2023
Post-finasteride syndrome and post-SSRI sexual dysfunction: Two clinical conditions apparently distant, but very close
Giatti S, Diviccaro S, Cioffi L, Cosimo Melcangi R
Frontiers in Neuroendocrinology
Open access
A clinical guide to rare male sexual disorders
Gül M, Fode M, Urkmez A, Capogrosso P, Falcone M, Sarikaya S, Sokolakis I, Morgado A, Morozov A, Albersen M, Russo GI, Serefoglu EC
Nature Reviews Urology
A clinical review of antidepressants, their sexual side-effects, post-SSRI sexual dysfunction, and serotonin syndrome
Marks S
British Journal of Nursing
(020) Post-SSRI/SNRI sexual dysfunction: A review
Pukall C
The Journal of Sexual Medicine
Open access
Estimating the risk of irreversible post-SSRI sexual dysfunction (PSSD) due to serotonergic antidepressants
Ben-Sheetrit J, Hermon Y, Birkenfeld S, Gutman Y, Csoka AB, Toren P
Annals of General Psychiatry
Open access
Post-SSRI sexual dysfunction and SSRI induced sexual dysfunction – literature review
Panek E, Jasłowski D, Rzeszutko M, Raczkiewicz P, Panasiuk D, Skrętowicz M, Szponarowicz P, Snopkowski B, Korzec T, Sosnowski J
Journal of Education, Health and Sport
Open access
The pathophysiology of post SSRI sexual dysfunction – lessons from a case study
Klaas S, Siva JB, Bak M, Govers M, Schreiber R
Biomedicine & Pharmacotherapy
Open access
2022
Disfunção sexual persistente e antidepressivos inibidores seletivos da recaptação da serotonina: Mito ou realidade?
Figueiredo CM, Freitas D, Ferreira M
Gazeta Médica
Open access
Cutting the first turf to heal post-SSRI sexual dysfunction: A male retrospective cohort study
De Luca R, Bonanno M, Manuli A, Calabrò RS
Medicines
Open access
Screening and treatment of post-selective serotonin reuptake inhibitors sexual dysfunctions
Achour V, Masson M, Lancon C, Boyer L, Fond G
Encephale
Post-selective serotonin reuptake inhibitor sexual dysfunctions (PSSD): Clinical experience with a multimodal approach
Reisman Y, Jannini TB, Jannini EA
Journal of Men’s Health
Open access
2021
Persistent sexual dysfunction after SSRI withdrawal: a scoping review and presentation of 86 cases from the Netherlands
Chinchilla Alfaro K, van Hunsel F, Ekhart C
Expert Opinion on Drug Safety
Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin
Healy D, Bahrick A, Bak M, Barbato A, Calabrò RS, Chubak BM, Cosci F, Csoka AB, D’Avanzo B, Diviccaro S, Giatti S, Goldstein I, Graf H, Hellstrom WJG, Irwig MS, Jannini EA, Janssen PKC, Khera M, Kumar MT, Le Noury J, Lew-Starowicz M, Linden DEJ, Lüning C, Mangin D, Melcangi RC, Rodríguez OWMAAS, Panicker JN, Patacchini A, Pearlman AM, Pukall CF, Raj S, Reisman Y, Rubin RS, Schreiber R, Shipko S, Vašečková B, Waraich A
International Journal of Risk & Safety in Medicine
Open access
Characterizing post-SSRI sexual dysfunction and its impact on quality of life through an international online survey
Studt A, Gannon M, Orzel J, Vaughan A, Pearlman AM
International Journal of Risk & Safety in Medicine
Exposure to serotonin selective reuptake inhibitors or serotonin noradrenaline reuptake inhibitors and sexual dysfunction: Results from an online survey
Patacchini A, Cosci F
International Journal of Risk & Safety in Medicine
Effects of paroxetine treatment and its withdrawal on neurosteroidogenesis
Giatti S, Diviccaro S, Cioffi L, Falvo E, Caruso D, Melcangi RC
Psychoneuroendocrinology
2020
Post-SSRI sexual dysfunction: Exploration of the sexual domains and symptoms
Raj S
Master thesis (Clinical Psychology), Utrecht University
Open access
Post-SSRI sexual dysfunction (PSSD): Ten year retrospective chart review
Waraich A, Clemons C, Ramirez R, Yih J, Goldstein S, Goldstein I
The Journal of Urology
Open access
Antidepressant-induced sexual dysfunction
Rothmore J
The Medical Journal of Australia
Open access
Post-SSRI sexual dysfunction
Reisman Y
The BMJ
Antidepressants and sexual dysfunction: a history
Healy D
Journal of the Royal Society of Medicine
Open access
Antidepressant use during development may impair women’s sexual desire in adulthood
Lorenz TK
The Journal of Sexual Medicine
Author manuscript is available in PubMed Central
A paradigmatic case of postselective serotonin reuptake inhibitors sexual dysfunction or withdrawal after discontinuation of selective serotonin reuptake inhibitors?
Patacchini A, Cosci F
Journal of Clinical Psychopharmacology
2019
Life after antidepressants: Does persisting sexual dysfunction influence quality of life?
Lüning C
Master Thesis (Clinical Psychology), Utrecht University
Open access
Post-SSRI sexual dysfunction: A bioelectric mechanism?
Healy D, LaPalme J, Levin M
Bioelectricity
Full article is available in PubMed Central
Are there any sex/gender differences in post-selective serotonin reuptake inhibitors (SSRI) sexual dysfunction (PSDD)?
Reisman Y
Current Sexual Health Reports
Post-SSRI sexual dysfunction & other enduring sexual dysfunctions
Healy D
Epidemiology and Psychiatric Sciences
Open access
Post-SSRI sexual dysfunction: Patient experiences of engagement with healthcare professionals
Healy D, Le Noury J, Mangin D
International Journal of Risk & Safety in Medicine
[See the full manuscript]
Towards improving post-SSRI sexual dysfunction by using nutriceuticals: Lessons from a case study
Calabrò RS, De Luca R, Manuli A, Portaro S, Naro A, Quattrini F
Journal of Sex & Marital Therapy
2018
Citizen petition: Sexual side effects of SSRIs and SNRIs
Healy D
International Journal of Risk & Safety in Medicine
Open access
Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases
Healy D, Le Noury J, Mangin D
International Journal of Risk & Safety in Medicine
Open access
Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin?
Giatti S, Diviccaro S, Panzica G, Melcangi RC
Endocrine
Post-SSRI sexual dysfunction: Preclinical to clinical. Is it fact or fiction?
Coskuner ER, Culha MG, Ozkan B, Kaleagasi EO
Sexual Medicine Reviews
2017
Disfunción sexual persistente tras el tratamiento con inhibidores selectivos de la recaptación de serotonina: a propósito de un caso tras la retirada de paroxetina
Muquebil Ali Al Shaban Rodríguez OW, Álvarez de Morales Gómez-Moreno E, Fernández Fernández J, Fresno García C, del Mar Fernández Fernández M
Psiquiatría Biológica
Post-SSRI sexual dysfunction: A literature review
Bala A, Tue Nguyen HM, Hellstrom WJG
Sexual Medicine Reviews
Open access
Sexual consequences of post-SSRI syndrome
Reisman Y
Sexual Medicine Reviews
2016
Persistent sexual dysfunction after early exposure to SSRIs: Systematic review of animal studies
Simonsen AL, Danborg PB, Gøtzsche PC
International Journal of Risk & Safety in Medicine
2015
Sexual dysfunction persisting after treatment with antidepressants (In Slovak)
Vašečková B
Psychiatria pre prax
Post-SSRI sexual dysfunction: Clinical characterization and preliminary assessment of contributory factors and dose-response relationship
Ben-Sheetrit J, Aizenberg D, Csoka AB, Weizman A, Hermesh H
Journal of Clinical Psychopharmacology
2014
Penile anesthesia in post SSRI sexual dysfunction (PSSD) responds to low-power laser irradiation: a case study and hypothesis about the role of transient receptor potential (TRP) ion channels
Waldinger MD, van Coevorden RS, Schweitzer DH, Georgiadis J
European Journal of Pharmacology
One hundred and twenty cases of enduring sexual dysfunction following treatment
Hogan C, Le Noury J, Healy D, Mangin D
International Journal of Risk & Safety in Medicine
Does sexual dysfunction persist upon discontinuation of selective serotonin reuptake inhibitors? (In Dutch)
Ekhart GC, van Puijenbroek EP
Tijdschrift voor Psychiatrie
Open access
2013
The impact of persistent sexual side effects of selective serotonin reuptake inhibitors after discontinuing treatment: a qualitative study
Stinson RD
PhD (Doctor of Philosophy) thesis, University of Iowa
Open access
2012
SSRIs and persistent sexual dysfunction
Netherlands Pharmacovigilance Centre Lareb
Open access
2009
Persistent sexual dysfunction in genitourinary medicine clinic attendees induced by selective serotonin reuptake inhibitors
Farnsworth KD, Dinsmore WW
International Journal of STD & AIDS
2008
Sexual side effects of antidepressant medications: An informed consent accountability gap
Bahrick AS, Harris MM
Journal of Contemporary Psychotherapy
Open access
Persistent sexual side effects after discontinuation of psychotropic medications
Kauffman RP
Primary Psychiatry
Persistence of sexual dysfunction side effects after discontinuation of antidepressant medications: Emerging evidence
Bahrick AS
The Open Psychology Journal
Open access
Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors
Csoka AB, Bahrick A, Mehtonen OP
The Journal of Sexual Medicine
Open access
2007
Prolonged post-treatment genital anesthesia and sexual dysfunction following discontinuation of citalopram and the atypical antidepressant nefazodone
Kauffman RP, Murdock A
The Open Women’s Health Journal
Open access
2006
Post SSRI sexual dysfunction
Bahrick AS
American Society for the Advancement of Pharmacotherapy Tablet
Open access
Persistent sexual side effects after SSRI discontinuation
Csoka AB, Shipko S
Psychotherapy and Psychosomatics
Genital anaesthesia persisting six years after sertraline discontinuation
Bolton JM, Sareen J, Reiss JP
Journal of Sex & Marital Therapy
Note: A list of academic literature about post-finasteride syndrome (PFS), which is generally regarded as a related condition to PSSD, can be found on the PFS Foundation website.