All DRESSed Up With Nowhere To Go

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August 9, 2022 | 4 Comments

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  1. New Drug Filing for Cenobamate Accepted for Review in Canada and Israel

    NEWS PROVIDED BY
    SK Biopharmaceuticals 

    Aug 09, 2022, 09:00 ET

    https://www.prnewswire.com/news-releases/new-drug-filing-for-cenobamate-accepted-for-review-in-canada-and-israel-301601069.html

    PANGYO, South Korea, Aug. 9, 2022 /PRNewswire/ — SK Biopharmaceuticals, Co., Ltd. announced that Health Canada has accepted Paladin Labs Inc.’s filing of a New Drug Submission (NDS) for cenobamate as an adjunctive therapy for the management of partial-onset seizures in adults with epilepsy who are not satisfactorily controlled with conventional therapy. If Health Canada approves this NDS, Paladin Labs would be able to launch cenobamate in Canada.

    https://www.ncbi.nlm.nih.gov/books/NBK573220/

    Cenobamate is a tetrazole carbamate anticonvulsant used as therapy of partial onset seizures in adults. Cenobamate is associated with a low-to-moderate rate of serum aminotransferase elevations during therapy and has been linked to cases of clinically apparent liver injury usually in the context of a multiorgan hypersensitivity syndrome such as drug reaction with eosinophilia and systemic symptoms (DRESS).

    https://practicalneurology.com/articles/2019-nov-dec/epilepsy-essentials-cenobamate#:~:text=At%20the%20time%20of%20the%20study%20data%20cutoff%2C,there%20was%20no%20autopsy%20in%20the%204th%20death.

    At the time of the study data cutoff, 1,037 participants were exposed to cenobamate for at least 196 days. There were 4 sudden deaths, 3 of which were reported as occurring because of traumatic intracranial hemorrhage (ICH), motor vehicle accident, and respiratory failure; there was no autopsy in the 4th death.

    No subsequent cases of DRESS were reported.9

    Celerion

    Make an Impact!

    Participate in a clinical study, and help people in your community and around the world.

     https://helpresearch.com/medical-study/ca35829-4a-0x00000000000055c4

    Healthy Normal Male and Female

    STIPEND: up to $6,000.00

    The DRESS Syndrome Community

    https://www.facebook.com/D.R.E.S.S.SyndromeCommunity/

    “An Alarm that must be heard.” …

  2. Gas Lighting on Trial(s)
    Maria was to my mind definitely a woman subjected to gaslighting – not yet, ,perhaps never a criminal offence although contributing to deaths.

    ‘Sixty seconds on . . . medical gaslighting’ (most of us , men as well,could contribute a lot more than 60 secs.)

    http://dx.doi.org/10.1136/bmj.o1974 Published: 09 August 2022
    Jacqui Wise

    Is this something to do with the Ingrid Bergman movie?
    That would be the 1944 film Gaslight, which tells the story of a man who manipulates his wife to such an
    extent that she doubts her own sanity. Since then, the term gaslighting has been widely used to describe any
    form of emotional abuse that makes someone question their own grasp of reality.
    Is Medical Gaslighting the sequel?

    No, it’s a term usually used to describe when a medical professional wrongly blames a patient’s symptoms
    on psychological factors such as stress or anxiety or tells them they are not really sick.
    Never heard of it—I think you’re imagining it
    Patients are increasingly sharing their stories of medical gaslighting on social media sites such as Instagram
    #medicalgaslighting. And two articles on the subject published in the New York Times this
    year have prompted thousands of responses.1 2 In one article a woman described going to a cardiologist with
    chest pains and being told to simply exercise more. Another woman who described weight loss, losing her
    hair, and developing a full body rash in her 20s was told by her male doctor that she was “young, healthy, 2
    and just lazy.” She was later given a diagnosis of the autoimmune disorder Graves’ disease.
    Are women particularly at risk?

    Women have reported that health problems such as endometriosis, fibromyalgia, and irritable bowel syndrome
    are often downplayed or dismissed by doctors. And studies have shown that, when compared with men
    women face longer waits to be given a diagnosis of cancer or heart disease, for example.3 But black people,
    geriatric patients, and LGBT+ people are also more likely to have their symptoms dismissed without a full
    investigation.
    Is it mainly doctors dismissing patients’ concerns?
    Not just that. A female Canadian doctor described being gaslit several times by colleagues in professional
    settings. She described specialist colleagues using their status to try to convince her of something she knew.
    to be false or not in the best interests of her patients.

    Is medical gaslighting becoming more common?
    The term has been used widely in connection with long covid, particularly early on in the pandemic. Some
    patients who were still experiencing symptoms months after infection with SARS-CoV-2 thought that they
    were not treated seriously, or investigated fully, by doctors.5 6
    1 Women are calling out “medical gaslighting.” New York Times. Mar 2022. https://www.nytimes.com/2022/03/28/well/live/gaslighting-doctors-patients

    2 Feeling dismissed? How to spot“medical gaslighting” and what to do about it. New York Times. July 2022. https://www.nytimes.com/2022/07/29/well/mind/med
    ical-gaslighting.html

    Wu J, Gale CP, Hall M, etal. Editor’s Choice – Impact of initial hospital diagnosis on mortality for acute myocardial infarction: A national cohort study. Eur Heart

    J Acute Cardiovasc Care 2018;7:-48. doi: 10.1177/2048872616661693. pmid: 27574333

    4 Fraser S. The toxic power dynamics of gaslighting in medicine. Can Fam Physician 2021;67:-8. doi: 10.46747/cfp.6705367. pmid: 33980633

    support-groups-symptoms/615382.
    Mariani M. The great gaslighting: how covid longhaulers are still fighting for recognition. Guardian. Feb 2022. https://www.theguardian.com/soci m
    ety/2022/feb/03/long-covid-fight-recognition-gaslighting-pandemic.

    the bmj | BMJ 2022;378:o1974 | doi: 10.1136/bmj.o1974 1

  3. AdDRESSing a different type of Dress – Seroxat Secrets was Here…

    Secret of the Tomb…

    GSK pouring salt into your wounds…

    https://seroxatsecrets.wordpress.com/2022/08/03/gsk-pouring-salt-into-your-wounds/

    August 3, 2022 — admin

    So… it’s been a while and as I’m sure people will be aware of, I don’t keep this blog up to date anymore.

    There has been lots of water under the bridge and I’ve been lucky in that I have (almost completely) recovered and there are so many more campaigners out in the world today than when I started writing this back in 2006.
    Sometimes though I hear some news that makes me want to scream – and today is one of those days.

    I saw this in a tweet – GSK Discontinues Production of Liquid Paroxetine (Seroxat).
    The tweet was from the good folks at Mad in America and I really had to read it a few times to let the news sink in… it’s beyond belief GSK is going to stop making liquid Seroxat.

    For all too many patients, the liquid formulation is the ONLY way that they can slowly taper off the drug in a way that works. With no tapering strips available (I don’t think?) or small dose tablets (1mg/0.5mg), people are going to be fucked without the liquid.

    I know – it took me almost 24 months to slowly reduce using the liquid back in 2004. Even using the liquid it was almost unbearable – and unachievable.

    And GSK have the absolute fucking brass neck to say“GSK has decided to discontinue manufacturing, supply and marketing of paroxetine hydrochloride oral suspension products. We recognise that paroxetine hydrochloride oral suspension is an important medicine for some patients and regret any inconvenience the discontinuation may cause.”

    It’s clear that the current GSK is exactly the same as the old GlaxoSmithKline.
    GSK does not care anything for patients that have been – and continue to be – damaged by their drug.

    I have no words.

    ‘Chemical imbalance’

    August 3, 2017 — admin

    https://seroxatsecrets.wordpress.com/2017/08/03/chemical-imbalance/

    Seroxat Secrets was a mine of information for those struggling with horrendous withdrawal and pumped up with chemicals from GlaxoSmithKline, and receiving this email just shows the passion people have retained for one of the most truly horrendous drugs ever to enter the market…

    This blog is still live, a mighty Tome, much and so much work over the years. Loyalty goes a long way as with Truthman and Fid Blog

    Who wants to invite Baum Hedlund to open an office in London…

    Cut a deal with Fortitude Law and get their £9.33 million back…

    And do something about Judge Lambert…

    Ridiculous – (GSK has a case to answer)

    The Fight for Pharma Accountability and Psychiatric Rights: Jim Gottstein, Esq
    August 2, 2022

    Awais Aftab, MD

    https://www.psychiatrictimes.com/view/the-fight-for-pharma-accountability-and-psychiatric-rights-jim-gottstein-esq

    For example, David Healy, MD, is on a mission to make the trial data available for review at the participant level, including being able to interview the participants. He makes the point it is outrageous the drug companies claim these data are trade secrets when volunteers risk harm for the benefit of society.

    As David Healy has commented, “… everything we know about what pharma gets up to comes from legal actions in the US and a handful of lawyers like Gottstein.”2 

    new job is at the Natural History Museum

    Government’s chief scientific adviser Sir Patrick Vallance will step down in April
    Famed appearing in Covid briefings his new job is at the Natural History Museum

    https://www.dailymail.co.uk/health/article-11076921/Sir-Patrick-Vallance-step-No10s-chief-scientific-adviser-spring.html

    2013-06-14 — The RIAT team sends an email to GSK, Sir Andrew Witty (CEO) and Patrick Vallance (President  of Pharmaceutical R&D), notifying them of the RIAT article publication and requesting that if they plan to restore any old GSK trials, they respond as soon as possible.

    https://study329.org/correspondence-with-gsk/

    Sir Patrick Vallance, who taught me at medical school, has announced he’s stepping down as the Government’s chief scientific adviser. During the dark days of the pandemic, I felt safe knowing he was guiding our response. He’s served us all admirably and I hope he now enjoys a well-deserved rest. – Max Pemberton 9/822

    Night at the Museum –

    Night at the Museum: Secret of the Tomb…

  4. Very glad to have the warning about DRESS Syndrome and meprobamate – because this drug is not “history” by any means. In the United States a drug called carisoprodol is commonly given as a “muscle relaxant” for pain and muscle spasms, especially with back injuries. Its brand name is SOMA (after the feel-good potion ladled out to the masses in Aldous Huxley’s Brave New World?). Meprobamate is its main metabolite. As the official leaflet makes clear, the first step in liver metabolism of this drug turns Soma into meprobamate:

    https://www.drugs.com/monograph/carisoprodol.html

    Soma can definitely be habit-forming all by itself – and it’s also become a player in the US opioid crisis. A combination of hydrocodone, Xanax and Soma earned the nickname of “Holy Trinity” due to the intense high it produced. Prescriptions for that combo became a red flag for law enforcement that a pain clinic was operating as a “pill mill” supplying drugs to addicted patients and drug dealers.

    Many (if by no means all) doctors know of Soma’s abuse potential – but I bet very few realize how dangerous an “allergic” or “hypersensitivity” reaction to this drug can be. Which means their patients will have no idea.

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