Post Minoxidil Syndrome

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January 26, 2022 | 4 Comments

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  1. Great post. I took minoxidil years after taking Zoloft for 10 years on and off.
    But once I took Minoxidil is exactly when I started to get the symptoms. I never knew if it was from SSRI or minoxidil.

    The fact you never took SSRI makes me believe it was minoxidil for my case.

    I informed Dr. Melcangi a year ago about Minoxidil possibly effecting me. He said it’s very possible but there is zero research on it.

  2. Thanks for writing this. I am in the same boat from applying rogain foam 5% on two beard patches twice a day for 3 months (so basically double dosed). This has brought me to my knees and and brought my already fragile marriage to the brink of divorce – the androgen deprivation has basically shrunk and softened my erections and of course getting erect without strong ED drugs is out of the question.

    It’s been 6 weeks now with no end in sight. Doctors agree the minoxidil is the most probable cause and my hypogonadism is apparent in my blood work. Unfortunately the drug of choice (proviron) is not available where I live so I am trying clomid for now or might switch to TRT in hope for a miracle, although there are studies that show penile atrophy is permanent.

    Don’t believe anything is safe just because it’s sold OTC – I have learned this the hard way.

  3. Participate in current PSSD related Research
    Post-Drug Syndrome Survey
    This survey will compare PSSD (Post SSRI Sexual Dysfunction), PFS (Post Finasteride Syndrome), PAS (Post Accutane Syndrome)
    Register for an account for the forum at https://forum.propeciahelp.com
    Open this link and reply to the post requesting to take the survey. You will then be sent a link.

    PSSD Study by Professor Fiametta Cosci (Associate Professor of Clinical Psychology at the University of Florence):
    Survey for Males
    Survey for Females

    PFS and PSSD Studies by Dr Roberto Melcangi (head of the Neuroendocrinology Unit in the Department of Pharmacological and Biomolecular Sciences at the University of Milano)
    request the questionnaire by emailing: roberto.melcangi@unimi.it
    The Mario Negri Institute is now collaborating with Maastricht University Neuroscience department on PSSD research. RxISK is involved with this. You can request to be added to an email list to participate in future research after completing a RxISK reprt:
    Complete a RxISK Report on THE RxISK website (RxISK is led by Dr David Healy, psychiatrist and psychopharmacologist, and is the most influential organisation in seeking to increase the profile of PSSD and encourage research):
    https://rxisk.org/experiencing-a-drug-side-effect/
    UK PSSD Association
    Contact: pssd-uk@protonmail.com
    Participate in current PSSD related Research

    Post-Drug Syndrome Survey

    This survey will compare PSSD (Post SSRI Sexual Dysfunction), PFS (Post Finasteride Syndrome), PAS (Post Accutane Syndrome)

    Register for an account for the forum at https://forum.propeciahelp.com
    Open this link and reply to the post requesting to take the survey. You will then be sent a link.

    PSSD Study by Professor Fiametta Cosci (Associate Professor of Clinical Psychology at the University of Florence):
    Survey for Males
    Survey for Females

    PFS and PSSD Studies by Dr Roberto Melcangi (head of the Neuroendocrinology Unit in the Department of Pharmacological and Biomolecular Sciences at the University of Milano)
    request the questionnaire by emailing: roberto.melcangi@unimi.it

    The Mario Negri Institute is now collaborating with Maastricht University Neuroscience department on PSSD research. RxISK is involved with this. You can request to be added to an email list to participate in future research after completing a RxISK reprt:

    Complete a RxISK Report on THE RxISK website (RxISK is led by Dr David Healy, psychiatrist and psychopharmacologist, and is the most influential organisation in seeking to increase the profile of PSSD and encourage research):
    https://rxisk.org/experiencing-a-drug-side-effect/

    UK PSSD Association
    Contact: pssd-uk@protonmail.com

  4. Alhetheli GI, et al. Post-Finasteride Syndrome:
    Current Views and Where do we Stand?. Ann Med Health Sci Res.
    2022;12:12-18.

    Introduction: Androgenetic alopecia is the most frequent cause of hair loss worldwide, affecting around 70% of males and 40% of females. Since the approval of finasteride for androgenetic alopecia, several studies have reported various psychological and sexual side effects. In 2012, the food and drug organization made changes to the drug insert stating the possibility of persistent side effects, or what is known as post-finasteride syndrome. There is still not much known about the rate of these side effects and the causal relationship. Methods: A literature search was performed using the Pubmed and Google Scholar databases that included studies conducted from 1995 to 2020. Results: There were 47 identified articles in Pubmed, while 152 articles were identified using Google Scholar. Duplicates were removed, leaving a total of 185 articles. Following a second, thorough screening of the titles and abstracts, only 62 full-text articles were reviewed. Of those, 35 articles were chosen to be included. Conclusion: Based on the existing literature, the medical community believes that these patterns of symptoms constitute the basis for PFS in individuals predisposed to epigenetic susceptibility. The medical community must define and characterize the pathophysiological mechanisms underlying PFS, and more attention should be devoted to patient education and counseling as well as to developing novel management modalities. Further highquality clinical studies are needed to evaluate the potential neuropsychiatric side effects of finasteride in humans and to establish whether finasteride has any exact causal relationship with suicidal ideation and other reported side effects.

    Full text https://www.amhsr.org/articles/postfinasteride-syndrome-current-views-and-where-do-we-stand.pdf

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