There have been some major developments on the RxISK Prize front.
First we are hovering around the $66,666 point – depending on how exchange rates go we may be wandering back and forth over this line as I write.
More important however is that San Marino has raced out in front as the donor leading country. This is down to one important woman and a small population. Her donation comes to roughly $1 for every 100 inhabitants.
Bill Gates lives in Washington State which has 7.6 million inhabitants – so Washington State could catch up if Bill donated some small change – $76,000. They might even take the lead as others from the state have already donated but not yet Bill.
Bill mustn’t have gotten the message. This could be as important as a vaccine. In this case we are talking about establishing how an adverse effect becomes enduring but, once we find that out, we may be able to make good effects enduring without having to take treatment endlessly. Come on Bill – $3.29 M would do it for the Entire United States.
Let’s hear your proposals for donations from wealthy individuals who could catch San Marino by donating their small change.
Thanks to the efforts of an Italian group who have been the most active national group there is now another reason to donate. The Mario Negri Institute in Milan, one of the most prestigious and independent research units in the world, have agreed to look more closely at PSSD with a view to setting up research on PSSD once things get back to normal. Mario Negri has a track record of making things happen and changing medicine in the process – see Good Pharma.
Interestingly some of the most active research on Post-Finasteride Syndrome (PFS) is also happening in Milan in Roberto Melcangi’s laboratory.
There have also been some interesting boundary developments. One was a study by Jalesh Panicker and colleagues at the Dept of Urology in UCL who appear to have come to a similar conclusion to one of the RxISK hypotheses – that this problem involves sensory receptors rather than damage to nerves or the nervous system. See Here.
Many, perhaps most people with PSSD, “feel” their brans are affected. The good news is that their brains likely aren’t affected but brains don’t work right when the input from the periphery has gone wrong and will work right again when the input is remedied.
What happens in PSSD is almost certainly central to what also happens in the kind of dependence and withdrawal that antidepressants and antipsychotics cause, and likely benzodiazepines as well. So, finding an answer to PSSD and PGAD will likely deliver us answers to withdrawal problems as well. The good news is that the brains of people with withdrawal problems are likely also okay – although they just don’t feel okay.
The opportunity to cure withdrawal needs to be part of the message to people out there who might want to do a San Marino on it.
Catching San Marino is not impossible. The US State of Georgia is currently fourth, after Wales and England, at roughly $1 per 2000 inhabitants – again mostly thanks to the generosity of one woman.
The race is far from over. San Marino could easily be caught by Iceland, the Isle of Man, fabulously wealthy Luxembourg, Andorra or maybe one of the US States like Wyoming, which only needs $6000 to catch up.
Prince Edward Island in Canada would need $1500. South Australia, which already leads in Australia, would need $16,000.
The Seychelles could do it for Africa on only $900 and the Maldives for Asia with about $3800
Even Mauritius could get there – everyone knows someone from Mauritius. They’re all over the place but still there are relatively few of them back at base, so a few ex-pats could do a lot.
San Marino is the fifth smallest national population in the world. A number of the South Sea Islands have even less people than San Marino and it would be great to see them give San Marino a run for its money.
Based on population, however, the place that could and really should lead the field is also within Italy, and historically has had a commitment to making babies. Come on Jose!
Word is spreading about PSSD and serious researchers are now looking into the issues – although the answer may yet come from someone with no research background who finds that something unexpected they take makes a difference – probably not bleach.
We need to blast past $100 K to ensure whoever finds an answer makes it publicly available to everyone immediately. For the record, we have more than one offer of making the sum up to $100 K if a real breakthrough appears – I’d be skeptical of one offer but we have more than one.