Health Canada has just concluded its review of persistent sexual dysfunction after stopping SSRIs and SNRIs. Let’s look at some of the background. January 2019 On 25 January 2019, we were contacted by the Marketed Pharmaceuticals and Medical Devices Bureau at Health Canada. They had become aware of our 2018 paper, “Enduring sexual dysfunction after […]
This 2020 closes in the middle of Covid19 and with the package leaflets of SSRI and SNRI antidepressants just updated in Europe with a new but evasive Warning: ‘Cases have been observed where symptoms of sexual dysfunction have persisted after discontinuation of treatment‘. Doctors, did you notice? Here I am. My sexual symptoms caused by […]
$100,000 target reached We are pleased to announce that the RxISK Prize, which was launched on 12 September 2017, has reached it’s goal of $100,000. This consists of money that has been donated as well as pledges from two generous donors who have provided written agreement to hand over money in the event that a […]
We first mentioned Transient Receptor Potential (TRP) Channels/ Receptors in several RxISK posts about withdrawal and they feature on the RxISK Complex Withdrawal Page under Ion Channels. The table on that page gives a fascinating list of herbs and other compounds that could conceivably play a part in stabilizing people who are having withdrawal problems. […]
This post is to honor the life, work, and words of our dear friend and regular blog contributor, Heather Roberts, who sadly we have learned died peacefully at her home on 20th October after a short illness. Heather campaigned alongside us in memory of her son, Olly, who had a severe adverse reaction to the […]
This post by J is about his withdrawal. He takes a different approach to the ones outlined in Side Effexor Withdrawal through to Helping H – an engineering approach rather than a therapy one. Next week we will feature a post about some of the TRP (Transient Receptor Potential) Channels he mentions. I usually work […]
A recent RxISK post on SSRI triggered Movement Disorders – My Doctor Thinks I’m Faking It – put together by Stevie Lewis, attracted less attention than we expected. This may be because it featured strange movements and few of us figure we are in a good position to make sense of strange movements. The movements […]
News flash: A big-city American newspaper (the Chicago Sun-Times) has written about the side effects of antidepressants, and how they can destroy marriages. It wasn’t on the Health page, or on the Business page where most of the important drug news appears. It was in Dear Abby’s advice column. You’ll find the letter from the […]
The Human Body is not meant to be taking ‘stuff’ all the time, whether medicines or biohack stuff or whatever. Forget the image of a magic bullet that flies to the one spot where it is needed and causes no collateral damage, every medicine poisons. The trick is to use medicines only when the damage […]
The following email arrived last week from someone who is unknown to me – has never filed a RxISK report about PSSD, never contributed to the RxISK Prize, never previously been in touch that I know of – at least under the name offered – doesn’t sign off, and is unwilling to engage in a […]
Two posts last week on RxISK Biohacking and david healy Stormy Weather raised issues about the Enduring Sexual Dysfunctions (ESD) linked to SSRIs and related drugs (PSSD and PGAD), finasteride and related drugs (PFS), and isotretinoin (PRSD). In the biohacking post both sides of the “debate” were concerned about the people with these conditions […]
This ambiguous picture comes up when you search under grave robbing – nothing you can make money out of is sacred. But its entitled grave digger. Digger, robber, it can be hard to tell. We had an email a few days ago about a young man desperately seeking help who had in good faith took […]
Editorial Note: This post by Stevie Lewis raises a very tricky area. There is no doubt that SSRIs cause movement disorders and not just temporary disorders but permanent problems like atypical Motor Neurone Disorder (ALS), Steele-Richardson Syndrome, Osmotic Demyelination Sydrome (Pontine Myelinolysis) and Multiple System Atrophy. There is also little doubt that most neurologists have […]
The expert inputs Managing Efexor and SSRI Withdrawal and Protracted Antidepressant Withdrawal to and comments on H’s case Side Effexor Withdrawal have been wonderful to get and hopefully will be a resource for others. Helping H H’s original problem and the idea of a commentary came about because 3 of us considered her case in […]
Following H’s report of difficulties with Effexor, we asked Will Hall, Altostrata, Bob Fiddaman and Josef Witt-Doerring, all experienced in this area, how they would Manage her Withdrawal. We also asked Peter Groot who helped develop the first Tapering Strips for Antidepressant withdrawal – who with colleagues has demonstrated that this can help many people […]
H’s nightmare with Effexor withdrawal was laid out in last week’s post. Experts on antidepressant withdrawal were asked to comment – Will Hall, Altostrata, Peter C Groot, Bob Fiddaman, Josef Witt-Doerring have generously given time to do so. James Moore, Stevie Lewis and Ed White, administrator for a Facebook venlafaxine withdrawal group, who have substantial […]
About 12 years ago I was diagnosed with mild depression and prescribed 75 mg effexor. I did achieve relief from my symptoms on this dose. Later, maybe a few years, my dose was increased to 150 mg when my job became more stressful. There was no discussion about duration of treatment. I used to be […]
Samizdat has just published Children of the Cure – the Preface of which is here This Book is not a Game. Quotes from the text are in Hand of History on davidhealy.org. Most of the first chapter is below. Flying to Philadelphia Shelley Jofre was 32 when she got on a plane to Philadelphia in […]
April’s Cosmopolitan features How Depression Stole my Orgasm – an article on Sex for sure… but Sex and Depression or Sex and Antidepressants? It’s worth downloading the full article and telling us what you think the message is. It opens with some pretty clear examples of how SSRIs have immediate effects on sex and can […]
There have been some major developments on the RxISK Prize front. First we are hovering around the $66,666 point – depending on how exchange rates go we may be wandering back and forth over this line as I write. More important however is that San Marino has raced out in front as the donor leading […]
The use of psychiatric meds in the U.S., already sky-high, is on the rise as a result of Covid-19. That’s not surprising – it happened after the 9-11 attacks, the 2008 crash and other crises. This graph comes from “America’s State of Mind,” an April 2020 report from Express Scripts. In the month from February […]
There are 3 bits to this post – an interview with Joan-Ramon Laporte. An article by Ariane Denoyel and a Q and A with Laporte and Healy. Laporte Interview As part of a series for ROAR Magazine, Frank Barat has run some striking interviews about aspects of the Covid pandemic not usually mentioned. Here […]
IN THE MIDST OF THE SARS-CoV-2 PANDEMIA, CAUTION IS NEEDED WITH COMMONLY USED DRUGS THAT INCREASE THE RISK OF PNEUMONIA. Joan-Ramon Laporte, M.D. Emeritus Professor of Clinical Pharmacology, Department of Pharmacology, Therapeutics and Toxicology Universitat Autònoma de Barcelona. Fundació Institut Català de Farmacologia. WHO Collaborating Centre for Research and Training in Pharmacoepidemiology. jrl@icf.uab.cat David Healy […]
Everyone who reads RxISK posts will know that SSRI and related drugs (some antibiotics, painkillers, antihistamines and most antidepressants) can cause sexual dysfunction. This has been known since 1961. And that they can cause suicide. This has been known since 1959. And that they can cause birth defects. The first publication by an Australian obstetrician, […]
Members of the British parliament In October 2019, we were contacted by a British PSSD sufferer who had done some excellent work in getting his Member of Parliament (MP), Steve McCabe, interested in the condition. We were informed that Mr. McCabe wanted to get a large group of MPs together to try and get some […]
Read the accompanying Sex, Withdrawal and Boundaries post first. We are looking for anyone interested in the material raised there to comment on or add to the set of questions below. We are so insensitive to the fact that our skin and gut principally, but also bladder and maybe the inner linings of our lungs, […]
“Do you think studying monolayers of cells will tell you why you fall in love with a girl?” The quote comes from Rudolf Hess, who won the Nobel Prize for physiology in 1949. His students remembered him as telling them never to study a neurotransmitter or even a cell without thinking about where this bit […]
This post gives the text of an article that has just been published online in the Journal of the Royal Society of Medicine – see Here. Another version of the material is in video form – Antidepressants and Sex: a Strange Story. Background In June 2019, in response to a petition, the European Medicines Agency […]
In the early 1960s, the American social psychologist, Stanley Milgram, ran now famous experiments using university students – then largely white and middle-class – as his subjects . His research interest lay in the Nazi concentration camps and the defence used by Adolf Eichmann (featured image) in his trial in Israel in 1962 – that […]
Up to 1800, no-one went near a doctor if they could avoid it. At best doctors might amuse the patient while nature cured the disease – the doctor’s business was to take as much of the credit and the money as possible. The best was rare. In an effort to get the money, doctors liked […]