Pyridoxal-5-Phosphate and Akathisia

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May 26, 2023 | 3 Comments


  1. Remarkable findings for you, with B6, P-5-P, and associated papers corroborated, to stop feelings of akathisia.

    Quite often, patients are given Propranolol :

    ‘Akathisia is a common adverse effect of antipsychotic drugs and is characterized by subjective feelings of restlessness. First-line treatment usually consists of propranolol, a beta adrenergic antagonist. However, propranolol does not seem to be efficacious in up to 70% of patients.

    This study was aimed to evaluate the effect of vitamin B6 versus propranolol on antipsychotic-induced akathisia (AIA).’

    I felt ok swallowing 28 Propranolol, throwing up but well enough to drive a few miles to the dog kennels to pick up my dog. The kennels owner decided to keep the dog for a while. I had bloody bandages on my wrists from self-mutilation a few hours earlier. My neck was chafed from rope.

    When I got home, I phoned a friend who insisted I went to A & E where I was given over-dose treatment and ferried across the loch to a general hospital. Again, Akathisia kicked in almost immediately, I guess the Propranolol was wearing off.

    Frantically looking for a way to end it all, I tried with a plastic bag in the ward toilet. I spent hours and hours pacing the corridors. No one seemed remotely concerned.

    For hours and hours I asked to see a doctor. My Seroxat was at home.
    I got the Seroxat very late that night and almost immediately was back to my normal self.
    I had hallucinated death, almost achieved death, but death was not meant to be.

    I think the point is that Propranolol does not stop Akathisia, except in large doses and then only for a limited amount of time –

    The Waves –

    The first time it happened was when I restarted Seroxat after a few weeks off it, which had gradually built up to a crescendo so unbearable I begged the GP to send me to a hospital.
    The resulting combination of Diazepam and Seroxat did the trick in a mental hospital.

    Suicidal ideation on my drive home, without Diazepam, resulted in an Akathisia attack three days later, as seen above.

    Why the GP did not tell the psychiatrist about the benzos and propranolol is extraordinary, considering the crisis. Why the psychiatrist did not tell the GP about the Diazepam is also extraordinary.

    Country practises, all close together had never been further apart.

    Any research done to achieve anything, is very welcome.

    Stewart Dolin got it in one “I don’t get it, Wen”

    Even today, “I don’t get it, Wen” is a suitable epitaph

    But, then, Wen did get it…

    • Yes I was given Propranolol it worked for about a day, but they didn’t stop making me take it.

      Common sense tells me it may well work well for people in benzo withdrawal akathisia, being as it is what the body uses to synthesize GABA from glutamate. I hope people caught up in this hell try it.

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