The Serotonin Reuptake Inhibitor (SRI) story starts in 1969 with Arvid Carlsson (above) who created Zelmid, the first SRI, after listening to people on antidepressants. He linked an anxiolytic effect some older drugs have to the serotonin system. The SRIs aimed at exploring that effect - Normality and Antidepressant Dysregulation. Fluoxetine (Prozac). sertraline (Zoloft). … [Read more...] about Restoring the Magic to Healthcare
akathisia
Deciphering the Web We Have Woven
Three people who got in touch recently, one with a problem, one with an idea, and one 'outraged' contributed to this post. The problem and idea illustrate what happens when doctors take Probity Blockers. The outrage tells you almost everything you need to know about the Web we are enmeshed in. Using the problem, idea and outrage, this post gives a punchier version of the … [Read more...] about Deciphering the Web We Have Woven
The Mysteries of Tapering – XX Rated
A woman on lamotrigine, a drug I never give anyone because of its withdrawal and other problems, recently came my way. She had been tapering for a long-time partly because lamotrigine can be a nasty drug to stop but primarily because her lamotrigine support group were firm Hyperbolic believers. An extraordinary number of people, primarily in my experience women, are … [Read more...] about The Mysteries of Tapering – XX Rated
No One Expects the Reformation
The title of this post borrows a famous line from Monty Python: No one expects the Spanish Inquisition This is an advance notice of things to come rather than a post per se. To get a sense of the things to come, it is worth reading the Antidepressants, Homicide and a Challenge post and the comments that come after it where many regular contributors to RxISK pick up … [Read more...] about No One Expects the Reformation
Antidotes for Akathisia and Dysregulation
A recent Mad in America Webinar on Antidepressant Dysregulation Syndromes introduced the idea that tapering might not be the only way to solve some of the problems SSRI antidepressants can cause. Tapering supporters give the impression tapering is the only legitimate way to go, leaving little or no room for the possibility that antidotes might help. Quite aside from … [Read more...] about Antidotes for Akathisia and Dysregulation
Madness, Normality and Antidepressant Dysregulation
Some weeks ago, Bob Whitaker asked me to do a Mad in America Continuing Education Webinar on the problems stopping Antidepressants. The talk with discussion is here Stopping Antidepressants and responses to points raised will be followed up in forthcoming posts. https://www.youtube.com/watch?v=YIlk1My4ZgQ I prerecorded the talk in case of disaster as Tapering … [Read more...] about Madness, Normality and Antidepressant Dysregulation
Complex Sensory Imbalances: New Remedies
In the Beginning The sulfonamides transformed medicine in the 1930s. They were the first effective antibiotics and they gave rise to the first diuretics, antihypertensives and hypoglycemics. The latest medical miracle, Semaglutide – Novo-Nordisk’s Ozempic - is touted not just as an effective hypoglycemic (anti-diabetic) medicine but also a Holy Grail drug that … [Read more...] about Complex Sensory Imbalances: New Remedies
Is Your Treatment Making You Suicidal?
This post links to a RxISK Reducing the Risk of Treatment Induced Suicide Resource. The immediate idea for this Resource came from an article by Katinka Newman on the Downward Spiral many prescription drugs can cause. Five years ago RxISK posted lists of drugs that can cause a downward spiral. Three years ago a mother of a 14 year old boy - see Mentally Hijacked by … [Read more...] about Is Your Treatment Making You Suicidal?
Juggling Our Selves and Our Bodies
Illustration: Juggling Act © 2020 created by Niki McQueen Balance in Balancing Our Bodies and Our Selves and Juggling or coordinating Our Selves and Our Bodies are closely linked. Life is a Tightrope Walk and Paul Klee's Tightrope Walker, emphatically concerned with his balance, features in Balancing. Once spotted Niki McQueen's extraordinary Juggling Act had to open this … [Read more...] about Juggling Our Selves and Our Bodies
Ondine’s Curse: Can’t Live With or Without
Ondine's Curse links closely to Balancing our Bodies and next week's Juggling our Selves. Ondine’s Curse sounds like a Greek Myths. Its not. The story began taking shape a few hundred years ago and has been elaborated ever since - ending up featuring in The Little Mermaid and other stories. The standard version is that a faithless man is cursed by Ondine, a water-nymph, … [Read more...] about Ondine’s Curse: Can’t Live With or Without