Drug Search by Year (Detail)

26546302

Altered state of consciousness, Acute kidney injury, Capillary leak syndrome, Dyspnoea, Rales, Sluggishness, Oedema peripheral,

GEMCITABINE HYDROCHLORIDE, FLUOROURACIL CREAM, 0.5%, FLUOROURACIL, LEVOLEUCOVORIN INJECTION, LEVOLEUCOVORIN CALCIUM, LEVOLEUCOVORIN, PANCRELIPASE, AMLODIPINE BESYLATE, METFORMIN, METFORMIN ER 500 MG, METFORMIN ER 750 MG, DULAGLUTIDE, LANSOPRAZOLE,

26535876

AU

Acute kidney injury, Liver abscess, Multiple organ dysfunction syndrome, Renal failure, Septic shock, Splenic abscess, Systemic candida, Candida infection, Oedema, Drug ineffective, Off label use,

PREDNISOLONE, PREDNISOLONE ORAL, PREDNISOLONE ORAL SOLUTION, ANAKINRA, CASPOFUNGIN ACETATE, DEXAMETHASONE, DEXAMETHASONE 1.5 MG, METHYLPREDNISOLONE SODIUM SUCCINATE, METHYLPREDNISOLONE, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL HYDROCHLORIDE, PEMBROLIZUMAB, TOCILIZUMAB, DEXAMETHASONE SODIUM PHOSPHATE, ACYCLOVIR, PENICILLIN G SODIUM, GENTAMICIN SULFATE, LEVETIRACETAM, LEVETIRACETAM IN SODIUM CHLORIDE, LEVETIRACETAM ORAL, LEVETIRACETAM INJECTION, MEROPENEM, NOREPINEPHRINE (BITARTRATE), NOREPINEPHRINE BITARTRATE, PANTOPRAZOLE SODIUM, PANTOPRAZOLE, PANTOPRAZOLE SODIUM IN 0.9% SODIUM CHLORIDE, PANTOPRAZOLE SODIUM INJECTION, PEMBROLIZUMAB, TRIMETHOPRIM, VANCOMYCIN HYDROCHLORIDE, VANCOMYCIN,

26536029

EU

Lactic acidosis, Acute kidney injury, Haemodynamic instability, Brain oedema, Brain herniation, Brain death, Hypoglycaemia, Intentional overdose, Hyperlactacidaemia, Hypotension, Generalised tonic-clonic seizure, Respiratory distress,

METFORMIN, METFORMIN ER 500 MG, METFORMIN ER 750 MG, METFORMIN, METFORMIN ER 500 MG, METFORMIN ER 750 MG,

26536348

EU

Renal vein thrombosis, Acute kidney injury,

IBUPROFEN, IBUPROFEN CAPSULES 200 MG, IBUPROFEN TABLETS USP, 200MG, IBUPROFEN TABLET, FILM COATED, IBUPROFEN ORAL, IBUPROFEN 200MG, IBUPFROFEN, IBUPROFEN TABLET, FILM-COATED, IBUPROFEN 200 MG, IBUPROFEN CAPSULE, IBUPROFEN, IBUPROFEN CAPSULES 200 MG, IBUPROFEN TABLETS USP, 200MG, IBUPROFEN TABLET, FILM COATED, IBUPROFEN ORAL, IBUPROFEN 200MG, IBUPFROFEN, IBUPROFEN TABLET, FILM-COATED, IBUPROFEN 200 MG, IBUPROFEN CAPSULE,

26536919

EU

Antiviral drug level above therapeutic, Toxic encephalopathy, Acute kidney injury,

VALACYCLOVIR, VALACYCLOVIR HYDROCHLORIDE, ACYCLOVIR SODIUM, ACYCLOVIR SODIUM, ACYCLOVIR SODIUM,

26536936

EU

Acute kidney injury,

PANTOPRAZOLE, PEMBROLIZUMAB, CARBOPLATIN, PACLITAXEL, PACLITAXEL (AIBUMIN-BOUND), ENALAPRIL, DAPAGLIFLOZIN, LEVETIRACETAM, LEVETIRACETAM IN SODIUM CHLORIDE, LEVETIRACETAM ORAL, LEVETIRACETAM INJECTION, APIXABAN,

26536941

EU

Rhabdomyolysis, Crush syndrome, Acute kidney injury, Palliative care,

ROSUVASTATIN, TRAZODONE HYDROCHLORIDE, EZETIMIBE,

26536942

EU

Acute kidney injury, Oedema peripheral,

CLARITHROMYCIN, AMLODIPINE, ACETAMINOPHEN, ACETAMINOPHEN 500MG, ACETAMINOPHEN TABLET EXTENDED RELEASE, PAIN RELIEVER,

26537044

EU

Altered state of consciousness, Acute kidney injury, Hepatic cytolysis, Cholestasis, Intentional overdose,

FLUOXETINE HYDROCHLORIDE, FLUOXETINE, QUETIAPINE,

26537312

US

Hydronephrosis, Renal tubular injury, Angioedema, Lip swelling, Acute kidney injury, Cellulitis, Erythema, Pruritus, Pustule, Pyrexia, Skin exfoliation, Leukocytosis,

26537611

US

Squamous cell carcinoma of the cervix, Sepsis, Acute kidney injury, Neuropathy peripheral, Weight decreased, Fatigue, Hypersomnia, Product prescribing issue,

TACROLIMUS, TACROLIMUS OINTMENT 0.1%, TACROLIMUS EXTENDED-RELEASE CAPSULES, TACROLIMUS, TACROLIMUS OINTMENT 0.1%, TACROLIMUS EXTENDED-RELEASE CAPSULES, TACROLIMUS, TACROLIMUS OINTMENT 0.1%, TACROLIMUS EXTENDED-RELEASE CAPSULES, TACROLIMUS, TACROLIMUS OINTMENT 0.1%, TACROLIMUS EXTENDED-RELEASE CAPSULES, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL HYDROCHLORIDE, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL HYDROCHLORIDE, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL HYDROCHLORIDE, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL HYDROCHLORIDE, PREDNISONE, PREDNISONE, PREDNISONE, PREDNISONE, DOCETAXEL, DOCETAXEL ANHYDROUS, DOCETAXEL, DOCETAXEL ANHYDROUS, DOCETAXEL, DOCETAXEL ANHYDROUS, DOCETAXEL, DOCETAXEL ANHYDROUS, DOCETAXEL, DOCETAXEL ANHYDROUS, DOCETAXEL, DOCETAXEL ANHYDROUS, DOCETAXEL, DOCETAXEL ANHYDROUS, DOCETAXEL, DOCETAXEL ANHYDROUS, HYDROXYCHLOROQUINE, HYDROXYCHLOROQUINE, HYDROXYCHLOROQUINE, HYDROXYCHLOROQUINE, CARBOPLATIN, CARBOPLATIN, CARBOPLATIN, CARBOPLATIN, CARBOPLATIN, CARBOPLATIN, CARBOPLATIN, CARBOPLATIN, CARBOPLATIN, CARBOPLATIN, CARBOPLATIN, CARBOPLATIN, BEVACIZUMAB, BEVACIZUMAB, BEVACIZUMAB, BEVACIZUMAB, TISOTUMAB VEDOTIN, TISOTUMAB VEDOTIN, TISOTUMAB VEDOTIN, TISOTUMAB VEDOTIN, PEMBROLIZUMAB, PEMBROLIZUMAB, PEMBROLIZUMAB, PEMBROLIZUMAB,

26537655

Acute kidney injury, Chronic kidney disease, Renal atrophy,

LETROZOLE,

26538148

US

Intentional overdose, Suicide attempt, Haemodynamic instability, Acute kidney injury, Depressed level of consciousness, Hypotension, Vomiting, Hypokalaemia,

LOSARTAN,

26538385

GB

General physical health deterioration, Malaise, Lethargy, Sepsis, Acute kidney injury,

CLOZAPINE, CLOZAPINE, CLOZAPINE, CLOZAPINE, BISOPROLOL FUMARATE, BISOPROLOL FUMARATE, BISOPROLOL FUMARATE, BISOPROLOL FUMARATE, DAPAGLIFLOZIN, DAPAGLIFLOZIN, DAPAGLIFLOZIN, DAPAGLIFLOZIN, DIGOXIN, DIGOXIN, DIGOXIN, DIGOXIN, RIVAROXABAN, RIVAROXABAN, RIVAROXABAN, RIVAROXABAN, SENNOSIDES, SENNA LEAF, SENNA, SENNOSIDES, SENNA LEAF, SENNA, SENNOSIDES, SENNA LEAF, SENNA, SENNOSIDES, SENNA LEAF, SENNA, SPIRONOLACTONE, SPIRONOLACTONE, SPIRONOLACTONE, SPIRONOLACTONE,

26538632

JP

Acute kidney injury,

AMLODIPINE BESYLATE, AMLODIPINE BESYLATE, AMLODIPINE BESYLATE, AMLODIPINE BESYLATE, TELMISARTAN, TELMISARTAN, TELMISARTAN, TELMISARTAN,

26538695

US

Acute kidney injury, Rebound effect, Pemphigoid, Respiratory failure, Haemolytic anaemia,

DEXAMETHASONE, DEXAMETHASONE 1.5 MG, DEXAMETHASONE, DEXAMETHASONE 1.5 MG, DEXAMETHASONE, DEXAMETHASONE 1.5 MG, DEXAMETHASONE, DEXAMETHASONE 1.5 MG, IPILIMUMAB, IPILIMUMAB, NIVOLUMAB,

26539264

KR

Acute kidney injury,

IRINOTECAN HYDROCHLORIDE,

26539338

EU

Pneumonia, Staphylococcal bacteraemia, Catheter site thrombosis, Thrombophlebitis septic, Arthritis bacterial, Respiratory distress, Acute kidney injury, Anaemia, Arthritis,

CAPECITABINE, PEMBROLIZUMAB, PANTOPRAZOLE, FOLIC ACID, BISOPROLOL FUMARATE, ACETAMINOPHEN, ACETAMINOPHEN 500MG, ACETAMINOPHEN TABLET EXTENDED RELEASE, PAIN RELIEVER,

26539538

ZA

Metabolic acidosis, Acute kidney injury, Vomiting, Abdominal pain, Headache, Diarrhoea, Dehydration,

KETAMINE HYDROCHLORIDE, MIDAZOLAM, MIDAZOLAM HYDROCHLORIDE,

26540224

EU

Renal vein thrombosis, Acute kidney injury,

KETOPROFEN,

26540709

AU

Acute kidney injury,

PEMBROLIZUMAB, CARBOPLATIN, PEMETREXED, PEMETREXED DISODIUM, ADAGRASIB, ADAGRASIB, DIAZEPAM, DIAZEPAM ORAL, DIAZEPAM ORAL SOLUTION (CONCENTRATE), DEXAMETHASONE, DEXAMETHASONE 1.5 MG,

26541139

Multiple organ dysfunction syndrome, Status epilepticus, Hyperthermia malignant, Sepsis, Small intestinal obstruction, Ventricular tachycardia, Cardiac arrest, Acute myocardial infarction, Acute kidney injury, Ischaemic hepatitis, Hyperkalaemia, Endotracheal intubation, Fatigue, Gait inability,

FENFLURAMINE, FENFLURAMINE, LACOSAMIDE, LEVETIRACETAM, CLOBAZAM, DIVALPROEX SODIUM, CLONAZEPAM, DIAZEPAM, FENTANYL, MAGNESIUM SULFATE, MAGNESIUM SULFATE HEPTAHYDRATE, MAGNESIUM SULFATE IN WATER FOR, MIDAZOLAM, MIDAZOLAM HYDROCHLORIDE, SODIUM CHLORIDE, SODIUM CHLORIDE TABLET, SODIUM CHLORIDE TABLETS, SUCCINYLCHOLINE CHLORIDE, VALPROIC ACID, SODIUM CHLORIDE, SODIUM CHLORIDE TABLET, SODIUM CHLORIDE TABLETS, DANTROLENE,

26543954

Diarrhoea, Dehydration, Acute kidney injury, Vomiting, Nausea, Fatigue, Headache, Dizziness,

BACTERIOSTATIC WATER,

26531230

EU

Respiratory failure, Respiratory syncytial virus infection, Arrhythmia supraventricular, Acute kidney injury, Insomnia,

ALLOPURINOL, PAROXETINE HYDROCHLORIDE HEMIHYDRATE, PAROXETINE, PAROXETINE HYDROCHLORIDE, PANTOPRAZOLE, BISOPROLOL FUMARATE, BISOPROLOL FUMARATE, SACUBITRIL AND VALSARTAN, FUROSEMIDE, EVOLOCUMAB, FOLIC ACID,

26531240

US

Anti-neutrophil cytoplasmic antibody positive vasculitis, Acute kidney injury, Off label use,

HYDRALAZINE HYDROCHLORIDE, NIFEDIPINE, FUROSEMIDE,

26531295

US

Milk-alkali syndrome, Mental status changes, Disorientation, Fatigue, Hypercalcaemia, Metabolic alkalosis, Acute kidney injury, Hypovolaemia, Dehydration, Dysarthria, Vitamin D deficiency, Blood 25-hydroxycholecalciferol decreased, Blood calcium increased, Blood chloride decreased, Blood creatinine increased, Blood glucose increased, Blood sodium decreased, Blood thyroid stimulating hormone decreased, Blood urea increased, Electrocardiogram QT prolonged, Heart rate increased, Overdose,

CALCIUM CARBONATE, ANTACID, METFORMIN, METFORMIN ER 500 MG, METFORMIN ER 750 MG, ROSUVASTATIN, METOPROLOL TARTRATE, METOPROLOL,

26531364

JP

General physical health deterioration, Dehydration, Acute kidney injury, COVID-19, Pyrexia, Decreased appetite, Malaise,

TELMISARTAN, AMLODIPINE BESYLATE,

26531558

Acute kidney injury,

FUROSEMIDE,

26531630

GB

Acute kidney injury,

DAPAGLIFLOZIN, RAMIPRIL, DOXAZOSIN, DOXAZOSIN MESYLATE, BUMETANIDE, SPIRONOLACTONE, ALLOPURINOL, ACETAMINOPHEN, ACETAMINOPHEN 500MG, ACETAMINOPHEN TABLET EXTENDED RELEASE, PAIN RELIEVER,

26531794

EU

Acute kidney injury, Breakthrough haemolysis, Hypertensive crisis,

SUTIMLIMAB-JOME,

26531874

US

Acute kidney injury, West Nile viral infection, Off label use,

PREDNISONE, DOXEPIN HYDROCHLORIDE, DOXEPN HYDROCHLORIDE, IXEKIZUMAB, CETIRIZINE, CETIRIZINE HYDROCHLORIDE, CETIIRIZINE, CEFTRIAXONE, CEFTRIAXONE SODIUM, VANCOMYCIN HYDROCHLORIDE, VANCOMYCIN, ACYCLOVIR, DOXYCYCLINE, DOXYCYCLINE HYCLATE,

26532128

EU

Acute kidney injury, Adrenal insufficiency,

OSILODROSTAT, OSILODROSTAT, TIRZEPATIDE, FENOFIBRATE, AMLODIPINE,

26532178

EU

Femoral neck fracture, Pneumonia, Subdural haematoma, Subdural haemorrhage, Acute kidney injury, Thrombocytopenia, Normochromic anaemia, Normocytic anaemia, Cardiac arrest, Fall, Mobility decreased, Disturbance in attention, Cardiomegaly, Arteriosclerosis coronary artery, Lymphadenopathy mediastinal, Hilar lymphadenopathy, Lung opacity, Lung infiltration, Pleural effusion, Sinus congestion, Coma, Anisocoria, Intracranial pressure increased, Hypotension, Haemodynamic instability, Sedation complication, Cerebral mass effect, Intracranial mass, Carotid artery stenosis, Pneumocephalus, Coagulation test abnormal, Miosis,

26532339

EU

Acute kidney injury, Hypocalcaemia, Hypomagnesaemia,

IBUPROFEN, IBUPROFEN CAPSULES 200 MG, IBUPROFEN TABLETS USP, 200MG, IBUPROFEN TABLET, FILM COATED, IBUPROFEN ORAL, IBUPROFEN 200MG, IBUPFROFEN, IBUPROFEN TABLET, FILM-COATED, IBUPROFEN 200 MG, IBUPROFEN CAPSULE, ZOLEDRONIC ACID,

26532720

IN

Acute kidney injury, Hypotension, Bradycardia, Lactic acidosis, Pulmonary oedema, Intentional overdose, Multiple organ dysfunction syndrome, Hypoglycaemia, Brain oedema, Cerebral congestion, Renal tubular necrosis, Cardiac arrest, Hepatic steatosis, Cholestasis, Pulmonary congestion, Completed suicide, Dehydration,

GLIMEPIRIDE, AMLODIPINE, METFORMIN, METFORMIN ER 500 MG, METFORMIN ER 750 MG, ENALAPRIL,

26533338

TN

Pancreatitis acute, Acute kidney injury, Gastrointestinal oedema, Biliary dilatation,

VALPROIC ACID, LEVETIRACETAM, LEVETIRACETAM IN SODIUM CHLORIDE, LEVETIRACETAM ORAL, LEVETIRACETAM INJECTION, LEVETIRACETAM, LEVETIRACETAM IN SODIUM CHLORIDE, LEVETIRACETAM ORAL, LEVETIRACETAM INJECTION,

26533378

EU

Haemodynamic instability, Lactic acidosis, Intervertebral discitis, Mycobacterium ulcerans infection, Pulmonary embolism, Acute kidney injury, Diabetes mellitus, Condition aggravated, Hypovolaemia, Fall, Muscular weakness, Head injury, Hypotension, Pain, Toxicity to various agents, Arteriosclerosis, Accidental overdose, Deep vein thrombosis, Septic shock, Contraindicated product administered,

METFORMIN, METFORMIN ER 500 MG, METFORMIN ER 750 MG, GABAPENTIN, FUROSEMIDE, ACETAMINOPHEN, ACETAMINOPHEN 500MG, ACETAMINOPHEN TABLET EXTENDED RELEASE, PAIN RELIEVER, ASPIRIN, ASPIRIN 81 MG, ASPIRIN 325 MG, PANTOPRAZOLE, SPIRONOLACTONE, PROPRANOLOL HYDROCHLORIDE, SEMAGLUTIDE, ORAL SEMAGLUTIDE,

26533527

EU

Acute kidney injury,

RITUXIMAB, CYCLOPHOSPHAMIDE FOR INJECTION, CYCLOPHOSPHAMIDE, CYCLOPHOSPHAMIDE INJECTION, SOLUTION,

26533633

Rash erythematous, Pyrexia, Myalgia, Acute kidney injury,

26533679

Acute kidney injury, Polyuria, Obstruction,

BUMETANIDE,

26533767

GB

Acute kidney injury,

BISOPROLOL FUMARATE, LANSOPRAZOLE, LOSARTAN,

26533795

Acute kidney injury,

LANSOPRAZOLE, LOSARTAN, BISOPROLOL FUMARATE,

26534119

GB

Rhabdomyolysis, Hyperkalaemia, Ischaemic cardiomyopathy, Acute kidney injury, Cardiac arrest, Blood creatinine increased, Loss of personal independence in daily activities, Contraindicated product administered, Condition aggravated, Product prescribing issue,

CLARITHROMYCIN, SIMVASTATIN,

26534251

EU

Eosinophilia, Acute kidney injury, Tubulointerstitial nephritis,

ENFORTUMAB VEDOTIN, PEMBROLIZUMAB, SITAGLIPTIN, METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA,

26534528

EU

Bone marrow failure, Acute kidney injury, Off label use,

PACLITAXEL, PACLITAXEL (AIBUMIN-BOUND), CARBOPLATIN,

26535070

ZA

Anuria, Generalised tonic-clonic seizure, Multiple organ dysfunction syndrome, Pulmonary oedema, Respiratory failure, Acute kidney injury, Circulatory collapse, Distributive shock, Harlequin syndrome, Hypoglycaemia, Intentional overdose,

AMLODIPINE BESYLATE, SIMVASTATIN, ENALAPRIL,

26535130

CN

Acute kidney injury, Hepatitis acute, Cholecystitis, Pancreatitis, Product use issue,

SEMAGLUTIDE,

26535327

ZA

Acute kidney injury, Headache, Back pain, Arthralgia, Chills, Hypotension, Tachycardia,

MIDAZOLAM, MIDAZOLAM HYDROCHLORIDE, CALENDULA, CALENDULA OFFICINALIS FLOWERING TOP, CALCIUM CARBONATE, ANTACID, MAGNESIUM CARBONATE, MAGNESIUM HYDROXIDE, SODIUM BICARBONATE, SODIUM BICARBONATE INJECTION,, ACTIVATED CHARCOAL,

26535459

JP

Acute kidney injury, Post transplant lymphoproliferative disorder, Haemophagocytic lymphohistiocytosis,

METHYLPREDNISOLONE, TACROLIMUS, TACROLIMUS OINTMENT 0.1%, TACROLIMUS EXTENDED-RELEASE CAPSULES, TACROLIMUS, TACROLIMUS OINTMENT 0.1%, TACROLIMUS EXTENDED-RELEASE CAPSULES, EVEROLIMUS, EVEROLIMUS TABLETS, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL HYDROCHLORIDE,

26535563

TW

Acute kidney injury,

PEMBROLIZUMAB, PEMBROLIZUMAB, CARBOPLATIN, CARBOPLATIN, PEMETREXED, PEMETREXED DISODIUM, PEMETREXED, PEMETREXED DISODIUM,

26535674

CA

Acute kidney injury, Urinary tract infection, Renal colic, Gastroenteritis, Ear pain, Pain in extremity,

UPADACITINIB,

26535784

US

Acute kidney injury, Impaired gastric emptying, Intentional product misuse,

TIRZEPATIDE, TIRZEPATIDE, TIRZEPATIDE, TIRZEPATIDE,

26537642

Acute kidney injury, Acute respiratory failure, Sepsis, Organ failure, Pulmonary oedema, Blood loss anaemia, Metabolic encephalopathy, Hypotension,

AMANTADINE, CARBIDOPA AND LEVODOPA, OMEPRAZOLE, OMEPRAZOLE MAGNESIUM, MIRTAZAPINE, CARBIDOPA, CARBIDOPA TABLETS, RASAGILINE MESYLATE, RASAGILINE, DOCUSATE SODIUM, DOCUSATE SODIUM 100MG, NALOXONE HYDROCHLORIDE NASAL, NALOXONE HYDROCHLORIDE,

26527058

ET

Multiple organ dysfunction syndrome, Non-cardiogenic pulmonary oedema, Cardiac arrest, Distributive shock, Respiratory distress, Toxicity to various agents, Acute kidney injury, Rhythm idioventricular, Hypoxia, Pleural effusion, Hypotension, Bradyarrhythmia, Peripheral coldness, Lethargy, Oedema, Vomiting, Bradycardia, Intentional overdose,

AMLODIPINE, DICLOFENAC, DICLOFENAC SODIUM,

26527071

US

Hyperkalaemia, Methaemoglobinaemia, Immune-mediated enterocolitis, Acute kidney injury,

DAPSONE GEL, 5%, DAPSONE, DASPONE, NIVOLUMAB, IPILIMUMAB,

26527122

US

Sepsis, Acute kidney injury,

LENALIDOMIDE,

26527138

JP

Acute kidney injury,

PEMBROLIZUMAB, PEMETREXED, PEMETREXED DISODIUM, CARBOPLATIN,

26527141

TR

Neuroleptic malignant syndrome, Acute kidney injury,

AMANTADINE HYDROCHLORIDE, LEVODOPA,

26527263

IN

Acute kidney injury, Hypotension, Bradycardia, Lactic acidosis, Pulmonary oedema, Dehydration, Multiple organ dysfunction syndrome, Hypoglycaemia, Brain oedema, Cerebral congestion, Renal tubular necrosis, Cardiac arrest, Hepatic steatosis, Cholestasis, Pulmonary congestion, Completed suicide, Intentional overdose,

AMLODIPINE, GLIMEPIRIDE, METFORMIN, METFORMIN ER 500 MG, METFORMIN ER 750 MG, ENALAPRIL,

26527495

ZA

Respiratory failure, Multiple organ dysfunction syndrome, Distributive shock, Shock, Pulmonary oedema, Anuria, Acute kidney injury, Generalised tonic-clonic seizure, Circulatory collapse, Hypoglycaemia, Hypotension, Intentional overdose,

AMLODIPINE, SIMVASTATIN, ENALAPRIL,

26527500

US

Acute kidney injury, Blood creatinine increased,

DOXORUBICIN, CISPLATIN, METHOTREXATE, METHOTREXATE SODIUM,

26527507

EU

Acute kidney injury, Metabolic acidosis,

METFORMIN, METFORMIN ER 500 MG, METFORMIN ER 750 MG,

26527553

Sprue-like enteropathy, Metabolic acidosis, Diarrhoea, Weight decreased, Hypotension, Acute kidney injury, Dehydration, Decreased appetite, Fatigue, Mobility decreased,

OLMESARTAN MEDOXOMIL, OLMESARTAN MEDOXOMIL, LEMBOREXANT, AMLODIPINE, BISOPROLOL FUMARATE, URSODIOL, URSOSIOL, ZOLPIDEM TARTRATE, LEUPROLIDE ACETATE, BICALUTAMIDE,

26527823

AU

Hyperkalaemia, Acute kidney injury, Drug level increased, Lactic acidosis, Drug interaction,

METFORMIN HYDROCHLORIDE, METFORMIN, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE TABLETS, METFORMIN HYDROCHLORIDE TABLET, METFORMIN HYDROCHLORIDE TABLETS, AMLODIPINE, ASPIRIN, ASPIRIN 81 MG, ASPIRIN 325 MG, SEMAGLUTIDE,

26527826

US

Acute kidney injury, Blood cholesterol increased, Nephrostomy, Blood magnesium decreased, Blood potassium increased,

DUPILUMAB, ENCORAFENIB, BINIMETINIB,

26527943

MA

Acute kidney injury, Myocarditis,

INTERFERON BETA-1A,

26528390

US

Toxicity to various agents, Mental status changes, Unresponsive to stimuli, Urinary incontinence, Dysarthria, Incoherent, Vomiting, Electrolyte imbalance, Acute kidney injury, Blood creatinine increased, Thrombocytopenia, Hyponatraemia,

LITHIUM, LITHIUM BROMATUM,

26528420

US

Acute kidney injury, Hypertension, Mucosal inflammation, Hypervolaemia,

METHOTREXATE, METHOTREXATE SODIUM, POTASSIUM CHLORIDE, POTASSIUM CHLORIDE EXTENDED-RELEASE, POTASSIUM CHLORIDE, DEXTROSE MONOHYDRATE, POTASSIUM CHLORIDE ORAL, SODIUM BICARBONATE, SODIUM BICARBONATE INJECTION,,

26528567

CA

Product prescribing error, Acute kidney injury, Duplicate therapy error,

CYCLOSPORINE, CYCLOSPORINE,

26528615

EG

Thrombocytopenia, Haematuria, Acute kidney injury, Hypoalbuminaemia, Hypocalcaemia, General physical health deterioration, Normochromic normocytic anaemia,

ANASTROZOLE, ANASTROZOLE TABLETS, ANASTROZOLE, ANASTROZOLE TABLETS, ANASTROZOLE, ANASTROZOLE TABLETS, ANASTROZOLE, ANASTROZOLE TABLETS, FENTANYL, FENTANYL, FENTANYL, FENTANYL,

26528636

AU

Acute kidney injury, Hyperkalaemia, Toxicity to various agents, Lactic acidosis, Drug interaction,

METFORMIN HYDROCHLORIDE, METFORMIN, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE TABLETS, METFORMIN HYDROCHLORIDE TABLET, METFORMIN HYDROCHLORIDE TABLETS, AMLODIPINE, ASPIRIN, ASPIRIN 81 MG, ASPIRIN 325 MG, SEMAGLUTIDE,

26528804

EU

Blood creatinine increased, Acute kidney injury,

LENALIDOMIDE, DEXAMETHASONE, DEXAMETHASONE 1.5 MG, SELINEXOR, SODIUM BICARBONATE, SODIUM BICARBONATE INJECTION,, AMLODIPINE BESYLATE, ACYCLOVIR, PANTOPRAZOLE, ZOLEDRONIC ACID, PANTOPRAZOLE, METOCLOPRAMIDE, METOCLOPRAMIDE HYDROCHLORIDE, APREPITANT, FOSAPREPITANT DIMEGLUMINE, APREPITANT, FOSAPREPITANT DIMEGLUMINE, NITROGLYCERIN, TADALAFIL, BORTEZOMIB,

26529055

AU

Acute kidney injury, Hyperkalaemia, Lactic acidosis, Toxicity to various agents, Drug interaction,

METFORMIN, METFORMIN ER 500 MG, METFORMIN ER 750 MG, AMLODIPINE, ASPIRIN, ASPIRIN 81 MG, ASPIRIN 325 MG, SEMAGLUTIDE,

26529067

EU

Acute kidney injury, Congenital thrombotic thrombocytopenic purpura, Back pain, Abdominal pain, Nausea, Vomiting,

FENTANYL,

26529180

EU

Pancytopenia, Hyperkalaemia, Acute kidney injury,

HYDROCHLOROTHIAZIDE, SULFAMETHOXAZOLE AND TRIMETHOPRIM,

26529425

US

Mucormycosis, Liver disorder, Drug ineffective for unapproved indication, Leukocytosis, Thrombocytopenia, Hypertransaminasaemia, Acute kidney injury, Haemorrhage, Hepatic artery aneurysm, Intestinal ischaemia, Hepatic necrosis, Slow response to stimuli, Hypothermia, Respiratory failure, Hyperbilirubinaemia, Product prescribing issue,

TACROLIMUS, TACROLIMUS OINTMENT 0.1%, TACROLIMUS EXTENDED-RELEASE CAPSULES, TACROLIMUS, TACROLIMUS OINTMENT 0.1%, TACROLIMUS EXTENDED-RELEASE CAPSULES, TACROLIMUS, TACROLIMUS OINTMENT 0.1%, TACROLIMUS EXTENDED-RELEASE CAPSULES, TACROLIMUS, TACROLIMUS OINTMENT 0.1%, TACROLIMUS EXTENDED-RELEASE CAPSULES, METHYLPREDNISOLONE, METHYLPREDNISOLONE, METHYLPREDNISOLONE, METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL HYDROCHLORIDE, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL HYDROCHLORIDE, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL HYDROCHLORIDE, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL HYDROCHLORIDE, PREDNISONE, PREDNISONE, PREDNISONE, PREDNISONE, AMPHOTERICIN B, AMPHOTERICIN B, AMPHOTERICIN B, AMPHOTERICIN B, DAPTOMYCIN, DAPTOMYCIN, DAPTOMYCIN, DAPTOMYCIN, CEFEPIME HYDROCHLORIDE, CEFEPIME, CEFEPIME HYDROCHLORIDE, CEFEPIME, CEFEPIME HYDROCHLORIDE, CEFEPIME, CEFEPIME HYDROCHLORIDE, CEFEPIME, MEROPENEM, MEROPENEM, MEROPENEM, MEROPENEM, PIPERACILLIN SODIUM AND TAZOBACTAM SODIUM, PIPERACILLIN AND TAZOBACTAM, PIPERACILLIN SODIUM,TAZOBACTAM SODIUM, PIPERACILLIN SODIUM AND TAZOBACTAM SODIUM, PIPERACILLIN AND TAZOBACTAM, PIPERACILLIN SODIUM,TAZOBACTAM SODIUM, PIPERACILLIN SODIUM AND TAZOBACTAM SODIUM, PIPERACILLIN AND TAZOBACTAM, PIPERACILLIN SODIUM,TAZOBACTAM SODIUM, PIPERACILLIN SODIUM AND TAZOBACTAM SODIUM, PIPERACILLIN AND TAZOBACTAM, PIPERACILLIN SODIUM,TAZOBACTAM SODIUM,

26529506

US

West Nile viral infection, Acute kidney injury, Off label use,

PREDNISONE, DOXEPIN HYDROCHLORIDE, DOXEPN HYDROCHLORIDE, CETIRIZINE, CETIRIZINE HYDROCHLORIDE, CETIIRIZINE, IXEKIZUMAB,

26529564

GB

Chronic kidney disease, Condition aggravated, Acute kidney injury, Carpal tunnel syndrome, Off label use,

SPIRONOLACTONE, FUROSEMIDE, FUROSEMIDE, APIXABAN, APIXABAN, OMEPRAZOLE, OMEPRAZOLE MAGNESIUM, ACETAMINOPHEN, ACETAMINOPHEN 500MG, ACETAMINOPHEN TABLET EXTENDED RELEASE, PAIN RELIEVER, COLCHICINE, ALLOPURINOL, SACUBITRIL AND VALSARTAN, EMPAGLIFLOZIN, BISOPROLOL FUMARATE,

26529755

EU

Acute kidney injury, Tubulointerstitial nephritis, Eosinophilia,

PEMBROLIZUMAB, METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA, SITAGLIPTIN, ENFORTUMAB VEDOTIN,

26529804

EU

Acute kidney injury, Lactic acidosis,

METFORMIN, METFORMIN ER 500 MG, METFORMIN ER 750 MG,

26529874

GE

Acute kidney injury, Toxic epidermal necrolysis, Mental impairment, Renal impairment, Rash erythematous, Oral disorder, Oliguria, Dyspnoea exertional, Asthenia, Pyrexia, Decreased appetite, Headache, Dizziness,

26529962

CN

Appendicitis, Abdominal pain lower, Cystitis, Dysuria, Acute kidney injury,

CYCLOSPORINE, CYCLOSPORINE, CYCLOSPORINE, CYCLOSPORINE, CYCLOSPORINE,

26530118

Adrenocortical insufficiency acute, Hepatitis cholestatic, Respiratory distress, Metabolic acidosis, Somnolence, Dehydration, Vomiting, Abdominal pain, Malaise, Peripheral coldness, Urine output decreased, Liver function test abnormal, Condition aggravated, Hypertransaminasaemia, Sinus tachycardia, Acute kidney injury, Nausea,

MOXIFLOXACIN, MOXIFLOXACIN HYDROCHLORIDE, RIFAMPIN, PYRAZINAMIDE, ISONIAZID, STREPTOMYCIN, METFORMIN HYDROCHLORIDE, METFORMIN, METFORMIN HYDROCHLORIDE EXTENDED-RELEASE TABLETS, METFORMIN HYDROCHLORIDE TABLET, METFORMIN HYDROCHLORIDE TABLETS,

26530153

Pancreatitis acute, Pancreatitis necrotising, Pancreatitis necrotising, Alcohol use, Lactic acidosis, Acute kidney injury, Acute respiratory failure, Ischaemic hepatitis, Distributive shock, Multiple organ dysfunction syndrome, Pathogen resistance, Escherichia infection, Blood culture positive, Hypotension, Haemofiltration,

SEMAGLUTIDE, ALCOHOL, ISOPROPYL ALCOHOL,

26530222

CA

Acute kidney injury, Renal tubular necrosis,

VANCOMYCIN HYDROCHLORIDE, VANCOMYCIN, ACETAMINOPHEN, ACETAMINOPHEN 500MG, ACETAMINOPHEN TABLET EXTENDED RELEASE, PAIN RELIEVER, CLINDAMYCIN PHOSPHATE, CLINDAMYCIN, DIMENHYDRINATE, LORAZEPAM, ONDANSETRON HYDROCHLORIDE, ONDANSETRON, ONDANSETRON TABLETS, PIPERACILLIN SODIUM,TAZOBACTAM SODIUM,

26530679

CA

Acute kidney injury,

VANCOMYCIN HYDROCHLORIDE, VANCOMYCIN, VANCOMYCIN HYDROCHLORIDE, VANCOMYCIN, ACETAMINOPHEN, ACETAMINOPHEN 500MG, ACETAMINOPHEN TABLET EXTENDED RELEASE, PAIN RELIEVER, CEFAZOLIN SODIUM, CEFAZOLIN, CICLESONIDE, CYCLOBENZAPRINE, DIAZEPAM, DIAZEPAM ORAL, DIAZEPAM ORAL SOLUTION (CONCENTRATE), DIMENHYDRINATE, DIPHENHYDRAMINE, DIPHENHYDRAMINE HYDROCHLORIDE, FERROUS SULFATE, LORAZEPAM, MELATONIN, MORPHINE, NAPROXEN, NAPROXEN SODIUM, ONDANSETRON HYDROCHLORIDE, ONDANSETRON, ONDANSETRON TABLETS, POLYETHYLENE GLYCOL,

26530776

EU

Confusional state, Renal impairment, Fatigue, Acute kidney injury, Anaemia, Drug interaction,

APIXABAN, APIXABAN, TRANDOLAPRIL, TRANDOLAPRIL TABLETS, BUMETANIDE, MAGNESIUM HYDROXIDE, TRANDOLAPRIL, TRANDOLAPRIL TABLETS, MIRABEGRON, DUTASTERIDE, GABAPENTIN, PREGABALIN, BISACODYL, BISACODYL SUPPOSITORIES, BISCODYL, LACTULOSE, POLYETHYLENE GLYCOL (3350), POLYETHYLENE GLYCOL 3350, POLYETHYLENE GLYCOL 400, INSTALAX POLYETHYLENE GLYCOL 3350, EPLERENONE, ALLOPURINOL, MELATONIN, SIMVASTATIN, ACETAMINOPHEN, ACETAMINOPHEN 500MG, ACETAMINOPHEN TABLET EXTENDED RELEASE, PAIN RELIEVER, PRAMIPEXOLE, FERROUS SULFATE,

26530904

EU

Acute kidney injury, Rhabdomyolysis,

ROSUVASTATIN,

26522691

JP

Macular oedema, Diarrhoea, Tinnitus, Deafness neurosensory, Acute kidney injury, Pancytopenia, Febrile neutropenia, Thrombocytopenia, Photophobia, Peripheral sensory neuropathy, Myelosuppression, Vision blurred, Drug-induced liver injury,

CISPLATIN, CARBOPLATIN, HEPARIN SODIUM, ETOPOSIDE,

26522922

Respiratory failure, Decompensated hypothyroidism, Acute kidney injury, Hyperthyroidism, Hypothyroidism, Bradycardia,

WARFARIN,

26522982

CA

Acute kidney injury, Aspergillus infection, Hyperkalaemia, Periostitis, Anaemia, Product use in unapproved indication,

TACROLIMUS, TACROLIMUS OINTMENT 0.1%, TACROLIMUS EXTENDED-RELEASE CAPSULES, TACROLIMUS, TACROLIMUS OINTMENT 0.1%, TACROLIMUS EXTENDED-RELEASE CAPSULES, PREDNISONE, VORICONAZOLE, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL HYDROCHLORIDE, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL HYDROCHLORIDE, RITUXIMAB, RITUXIMAB,

26523189

AU

Acute kidney injury, Pneumonia, Toxicity to various agents,

AMLODIPINE, CITALOPRAM, CITALOPRAM HYDROBROMIDE, TRAMADOL HYDROCHLORIDE, AMPHETAMINE, DIAZEPAM, DIAZEPAM ORAL, DIAZEPAM ORAL SOLUTION (CONCENTRATE), HYDROMORPHONE HYDROCHLORIDE, METHADONE HYDROCHLORIDE, METHADONE, MORPHINE, OXAZEPAM, ACETAMINOPHEN, ACETAMINOPHEN 500MG, ACETAMINOPHEN TABLET EXTENDED RELEASE, PAIN RELIEVER, TEMAZEPAM,

26523249

US

Cardio-respiratory arrest, Lupus-like syndrome, Acute febrile neutrophilic dermatosis, Encephalopathy, Antineutrophil cytoplasmic antibody positive, Acute kidney injury, Subcapsular splenic haematoma,

HYDRALAZINE HYDROCHLORIDE, METOPROLOL TARTRATE, METOPROLOL, ACYCLOVIR,

26523302

US

Sepsis, Acute kidney injury, Oedema,

ENOXAPARIN SODIUM,

26523319

EU

COVID-19, Encephalitis herpes, Hypoglycaemia, Hypothermia, Sinusitis, Acute kidney injury, Pneumonia,

OCRELIZUMAB, OCRELIZUMAB, PREDNISOLONE, PREDNISOLONE ORAL, PREDNISOLONE ORAL SOLUTION, DENOSUMAB, RANITIDINE HYDROCHLORIDE, RANITIDINE HYDROCHLORIDE, PREDNISOLONE, PREDNISOLONE ORAL, PREDNISOLONE ORAL SOLUTION, PREDNISOLONE, PREDNISOLONE ORAL, PREDNISOLONE ORAL SOLUTION, TIZANIDINE, DALFAMPRIDINE, RAMIPRIL, MIRABEGRON, PANTOPRAZOLE SODIUM, PANTOPRAZOLE, PANTOPRAZOLE SODIUM IN 0.9% SODIUM CHLORIDE, PANTOPRAZOLE SODIUM INJECTION, NIFEDIPINE, ROMOSOZUMAB-AQQG, CEFTRIAXONE, CEFTRIAXONE SODIUM, REMDESIVIR, QUETIAPINE, ACYCLOVIR, THIAMINE HYDROCHLORIDE, VALSARTAN, VALSARTAN ORAL, DEXAMETHASONE, DEXAMETHASONE 1.5 MG, DEXTROSE MONOHYDRATE, DEXTROSE,

26523321

EU

Acute kidney injury, Tubulointerstitial nephritis,

PEMBROLIZUMAB,

26523394

EU

Haemodynamic instability, Fall, Muscular weakness, Head injury, Acute kidney injury, Pain, Septic shock, Hypovolaemia, Mycobacterium ulcerans infection, Condition aggravated, Arteriosclerosis, Deep vein thrombosis, Intervertebral discitis, Toxicity to various agents, Diabetes mellitus, Pulmonary embolism, Hypotension, Lactic acidosis, Accidental overdose, Contraindicated product administered,

METFORMIN, METFORMIN ER 500 MG, METFORMIN ER 750 MG, METFORMIN, METFORMIN ER 500 MG, METFORMIN ER 750 MG, ASPIRIN, ASPIRIN 81 MG, ASPIRIN 325 MG, GABAPENTIN, FUROSEMIDE, ACETAMINOPHEN, ACETAMINOPHEN 500MG, ACETAMINOPHEN TABLET EXTENDED RELEASE, PAIN RELIEVER, PANTOPRAZOLE, PROPRANOLOL HYDROCHLORIDE, SPIRONOLACTONE, SEMAGLUTIDE, ORAL SEMAGLUTIDE,

26523401

US

Rhabdomyolysis, Acute kidney injury, Drug interaction,

RIFAXIMIN, LACTULOSE,

26523613

IN

Acute kidney injury, Hypotension, Bradycardia, Lactic acidosis, Pulmonary oedema, Intentional overdose, Multiple organ dysfunction syndrome, Hypoglycaemia, Brain oedema, Cerebral congestion, Renal tubular necrosis, Cardiac arrest, Hepatic steatosis, Cholestasis, Pulmonary congestion, Completed suicide, Dehydration,

AMLODIPINE, ENALAPRIL, GLIMEPIRIDE, METFORMIN, METFORMIN ER 500 MG, METFORMIN ER 750 MG,

26523809

US

Acute kidney injury, Hypotension, Hypokalaemia, Depressed level of consciousness, Intentional overdose,

LOSARTAN,