Overview | p53 | p63 | ACE-2 | Prokineticin | Kisspeptin | VEGF | Epigenetics | Neuropathy | Studies
P53 is described as the Guardian of the Genome.
The articles below give you a feel for its role in skin as well. Skin will sound trivial to most people, but it is the boundary between us and the world. Our brains and nervous system derive from ancestral skin (epithelial) cells, and skin cells are full of sensory organs and neurotransmitters.
The articles below will make you aware of links between the drugs of interest to us and the conditions we are trying to solve.
Articles
p53/p63/p73 in the Epidermis in Health and Disease
Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies
The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation
p53: key conductor of all anti-acne therapies
Skin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior
Penile apoptosis in association with p53 under lack of testosterone
What about these articles that seem to link p53 to the libido and sexual organs?
Skin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior
https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01013-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124721010135%3Fshowall%3Dtrue
Penile apoptosis in association with p53 under lack of testosterone
https://www.researchgate.net/publication/8950312_Penile_apoptosis_in_association_with_p53_under_lack_of_testosterone
This paper from the University of Konstanz explore P53’s role in regulation of the epi-genome.
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01429-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124722014292%3Fshowall%3Dtrue