p53

Overview | p53 | p63 | ACE-2 | Prokineticin | Kisspeptin | VEGF | Epigenetics | Neuropathy | Studies

P53 is described as the Guardian of the Genome.

The articles below give you a feel for its role in skin as well. Skin will sound trivial to most people, but it is the boundary between us and the world. Our brains and nervous system derive from ancestral skin (epithelial) cells, and skin cells are full of sensory organs and neurotransmitters.

The articles below will make you aware of links between the drugs of interest to us and the conditions we are trying to solve.

Articles

p53/p63/p73 in the Epidermis in Health and Disease

Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies

The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation

p53: key conductor of all anti-acne therapies

Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris

Skin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior

Penile apoptosis in association with p53 under lack of testosterone

Comments

  1. What about these articles that seem to link p53 to the libido and sexual organs?

    Skin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior

    https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01013-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124721010135%3Fshowall%3Dtrue

    Penile apoptosis in association with p53 under lack of testosterone

    https://www.researchgate.net/publication/8950312_Penile_apoptosis_in_association_with_p53_under_lack_of_testosterone

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