International Society of Sexual Medicine

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May 8, 2023 | 10 Comments


  1. Dr. Healy,

    I appreciate your attention to this matter. The PSSD Reddit and Twitter community worked together to create a powerful outcry.

    It has been three years since the EMA acknowledged the persistence of sexual issues post-discontinuation. There is no justification for allowing such a high degree of misinformation to persist.

    Let us hope that the ISSM has learned from this experience.


  2. It should be clarified, that severe depression doesn’t cause numbed genitals only in a drug-naive population which never got treated. If someone had previous exposure to SSRI depression or stress then depression indeed can cause or worse numbed genitals. This is evident from many testimonies and speaks about persistent asymptomatic damage being masked by good mental health. SSRI Damage becomes symptomatic after worsening of mental state. The stress – symptoms severity correlation is true also for akathisia, emotional bluting and tardive dyskinesia. Given the mass usage of SSRI It’s easy for some opinion leaders to push the idea that depression always caused numbed genitals, but the symptom was overlooked in older research / diagnostic system

    • S – genital numbness is not and has never been a symptom of depression. People on finasteride and isotretinoin also get this genital numbness and its not part of losing your hair or developing acne either


  3. May 10, 2023 at 1:38 pm
    Your comment is awaiting moderation. This is a preview; your comment will be visible after it has been approved.
    1 of 5 TOMORROW! Inspiration, Hope, and Healing: Psychiatric Drug Withdrawal Success Stories Inbox IIPDW 3:44 PM (2 hours ago) IIPDW logo This is one last reminder for the online panel discussion TOMORROW 9am PDT/12pm EDT/5pm BST, which we’ve created in partnership with Mad in America. The discussion will be hosted by James Moore, who will talk with three guests who have each successfully come off their psychiatric drugs. Brooke Siem is a recognized writer and award-winning chef who healed from withdrawal. She is the author of May Cause Side Effects and Food Network Chopped champion. Gemma Da Costa works for the UK’s Crown Prosecution Service. After healing from withdrawal, she began supporting others and created a YouTube channel to share hope. Michael Priebe is a writer and wellness coach who experienced withdrawal. Through his Lovely Grind coaching, blog and YouTube channel, he inspires thousands of people each month. James Moore experienced withdrawal and is an advocate for greater awareness of tapering safely. He hosts and produces the Let’s Talk Withdrawal and Mad in America podcasts. Speakers will share their withdrawal journeys and consider what contributed most to their success. At the end of the discussion, there will be some time for audience questions. Tickets are $10 and will go towards supporting both of these non-profit organisations. We understand not everyone can afford a ticket at this time, if so please use code successstories for a free ticket. If you’d like to tell friends or colleagues about this event, you can download the event flyer here.
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  4. From the Vortioxetine paper mentioned: Conflicts of Interest: A.C. (Anita Clayton) reports grants from Endoceutics, Janssen Pharmaceutica, Sage Therapeutics, and Takeda Pharmaceuticals; advisory board or consultant fees from Acadia, Alkermes, Allergan, AMAG Pharmaceuticals, Fabre-Kramer, Lundbeck, Otsuka, Palatin Technologies, S1 Biopharma, Sage Therapeutics, Sprout Pharmaceuticals, and Takeda Pharmaceuticals; royalties or copyrights from Ballantine Books, Changes in Sexual Functioning Questionnaire, and Guilford Publications; and shares or restricted stock units from Euthymics and S1 Biopharma.

    P.J., W.Z., and G.N. were employees of Takeda Development Center Americas, Inc., at the time of the study.

    Funding: This study was funded by Takeda Pharmaceuticals U.S.A. The sponsor was involved in study design and implementation, analysis and interpretation of the data, writing of the report, and the decision to submit the article for publication.

    Medical writing assistance was provided by inVentiv Medical Communications, LLC, a Syneos Health group company, and supported by Takeda Pharmaceuticals U.S.A., Inc.

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