This weeks post was supposed to be just about Sexual Mysteries. What’s in a Touch?
As it was waiting to be posted, a controversy blew up about the International Society of Sexual Medicine and claims by Dr Anita Clayton that there is no such thing as PSSD.
There did not seem to be enough for a post in its own right but equally it seemed to make sense to say something and so a comment was added to an important post about Affective Touch.
Since posting the combined post, many people have been in touch about Dr Clayton and Vortioxetine and all the comments so far have been on this topic which risks drowning out an in the longer run more important message about Affective Touch. So RxISK has opted to take a step never taken before which is to switch the Clayton material into its own post and add the comments linked to this below.
Since posting the material below ISSM have delisted the Clayton video. This may be because of the comments from folk with PSSD – the ones I saw were all reasonable. Or it may be because folk have been in touch with ISSM and pointed out just how wrong and inappropriate this video was.
For those still interested to see the offending video – the link below should still work.
Conflict of Interest Mysteries
It is a pity to distract from the important issues above, but there has been a recent event that has caused a degree of consternation among PSSD folk.
The International Society for Sexual Medicine has just released a brief video on PSSD featuring Cobi Reisman and Anita Clayton.
Cobi gives the standard view, mentioning the Diagnostic Criteria.
Dr Clayton takes a very different appoach. She dismisses PSSD as an entity suggesting folk are depressed and in need of a better antidepressant like Vortioxetine. As it turns out she is an author on this Vortioxetine Paper saying it is better for sexual function than paroxetine. The conflict of interest statement at the end is interesting. She is on more than one Vortioxetine paper in fact.
There are prior RxISK posts about Vortioxetine causing a very SSRI like suicidality – just like paroxetine – See We Should talk about Brintellix.
RxISK also has a growing number of PSSD reports from people taking Brintellix, Trintellix, Vortioxetine – 6 at the latest count.
When we sent a petition to EMA to get a mention of PSSD added to drug labels, EMA exempted Vortioxetine – perhaps because it was relatively recent and on patent so Lundbeck were still making money on it. Perhaps back then – 4 years ago – there were so few Vortioxetine reports. It speaks to the power of companies that they can manage this.
Lundbeck used to described themselves as different to other companies – they were a Foundation. They implied they were more ethical. But with Vortioxetine they have shamelessly tried to exploit the market for SSRIs in children – running a huge trial in the Russian Federation and a range of other out of the way countries where many would be concerned about the quality of the trial data. They didn’t put this not so wonderful drug into trials in Denmark using Danish children.
The message isn’t all grim though. While people like Dr Clayton go around saying Vortioxetine is the next best thing to the Eucharist, she sells the message that the other drugs you might take are not.
Other companies have been in touch with me wondering if I’d endorse their drug and say that unlike others it doesn’t cause PSSD. I have not been willing to do so.
Some time there might finally be a drug that doesn’t cause PSSD, and the company making it will tell Dr Clayton to stress that PSSD is a real and devastating condition that other drugs really do cause – and this is not depression – depression never makes your genitals number. When that day arrives, the world will properly wake up to PSSD. Until then, any talk about PSSD, even if not on message all helps move things forward.
Vortioxitine ruined my life I have PSSD for years because of this drug. I have been on many antidepressants and had no problems with sexual functioning until I took Vortioxitine
Something else that Dr Clayton doesn’t realise is that many PSSD sufferers have already tried non-SSRI/SNRI antidepressants to no avail. If vortioxetine worked for PSSD, we would already know. I personally have tried it and it did nothing for my mood or sexual function. The only impressive thing about it was that it didn’t have any horrendous side effects that one would see with any SSRI.
It’s very interesting that she is suggesting vortioxetine as a treatment for a condition she doesn’t believe exists!
I think this post is correct though: the biggest PSSD breakthroughs will come when an AD is discovered that doesn’t cause sexual dysfunction. The patent-holding pharmaceutical company would be very wise to spend some money on the catastrophe that is PSSD.
The website for the International Society for Sexual Medicine reveals that their Conflict of Interest Committee is staffed by… Anita Clayton herself!
The question is: why didn’t they declare her CoIs beneath this video?
I imagine they will respond by saying these are her genuinely held beliefs and this therefore is not a conflict of interest.