Side Effexor Withdrawal

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June 17, 2020 | 44 Comments

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  1. Interesting post. I just want to add just in case it might help anyone, when I was on mirtazapine and when I was withdrawing from it I used to get the odd boil appear on my face. It used to start with itching and I also had itchy skin all over my body but the boils only appeared on my face.

    Well I tried every cream going I even tried an over the counter facial cream from boots (recommended by pharmacist) I think the name was something like “freedom” but it gave me terrible acne so I stopped using it. I was then told by another pharmacist that the same cream had had the same affect on her skin too and she advised me to stop using it.

    Anyway to cut a long story short I then came across teatree oil and witch hazel night gel treatment. I used this with E45 moisturising lotion and it improved my skin beyond belief. I still had the odd boil try to appear but teetree oil and E54 moisturising lotion reduced it significantly until I was well over my withdrawral which I would say was about a year and a half after stopping the medication.

    I no longer get itchy facial boils and my skin is no longer dry and itchy. I now know this was down to mirtazapine.

    If it helps try to use something like E45 or Diprobase for dry crawly itchy skin if withdrawing from any medication you feel could be causing your skin problems.

    • TO THE AUTHOR OF THIS ARTICLE: I was on Effexor 75 mg for 4 months. I was prescribed it by a general practitioner. I went to her with complaints of insomnia. Instead of suggesting Benadryl, natural herbs, or a calcium fizzy drink, she prescribed me 75 mg of Effexor. The starting dose is 37.5 mg. I felt GREAT taking 75 mg and was hooked from the first day. I was too ignorant to realize I was hypomanic. Four months later, I crashed. This is natural when you get used to being on a drug you don’t need. So, this general practitioner with a specialty in Internal Medicine, doubled the dose to 150 mg. She claimed my depression was a relapse. (I wasn’t depressed to begin with, however. This was now the fallout of being hypomanic for 3 months.) From that point forward 6 years, I was a zombie. I had to rely upon the “kindness” of strangers for housing and help. I functioned as a person with mental illness and lived like a ghost in society. If you don’t need psychotropic drugs and you take them, it induces artificial mental illness. All I needed to do AFTER I CRASHED was down dose the drug. Instead my GP doubled the dose. Unfortunately, I believed her and taking 150 mg ruined my life.

      During those 6 years on 150 mg of Effexor, I had scales on my scalp, enlarged tonsils, frequent runny nose, little bumps on my neck, constipation, dry skin, cravings for sugar and alcohol, blurred vision, and a very bloated stomach. I also gained abdominal fat for the 1st time in my life. Those were just the physical symptoms. I had psychological ones, too, such as nightmares and blunted cognition and blunted affect.

      Once I saw real psychiatrist and talked with him about these symptoms, he told me that I was poisoning myself with Effexor and I had a fatty acid deficiency. This was indicated by my scales, tonsils, runny nose, and mysterious neck bumps.

      Once I came off the Effexor, I realized that I had permanent damage to my brain and limbic system. I literally cannot function more than a week without half an adult dose of an anti-seizure medication used off-label as a mood stabilizer. I also take half the amount of a mild anti-anxiety medication. I take these 2 meds with a calcium fizzy drink at BEDTIME only because they knock me out and if I take them in the morning, I fall back to sleep. If I don’t take meds, I become suicidal. I was never like this before taking Effexor… for insomnia.

      I think you are POISONING YOURSELF and I think that your symptoms could be lessened by down dosing to the lowest amount of Effexor you “need” to function. Effexor does really weird stuff to our bodies and brains, and some Effexor survivors NEVER come off of the drug because they’re permanently hooked. However, you need to reduce your intake of this powerful drug. Your skin issues may go away (?) if you down dose and add essential fatty acid supplements to your diet. Research brain health diet plans & supplements. You could have inflammation from the Effexor so reducing your intake & following an anti-inflammatory diet could help reduce your symptoms.

      • Effexor is a nasty drug. I’ve been trying to taper for months. I ended up in the hospital for several days because the doctors do not believe this is due to withdrawal. I know without a doubt what I experience is because of this drug. I have to continue low dose it because I’m not in a position in my life to be sick for months. I have to continue to take a small amount everyday just to survive. The saddest thing is, I was prescribed this to alleviate anxiety which was occasional but extreme. No anxiety medicine tho, just this crap that they say is not addictive. I think every single doctor who wants to prescribe it should have to take it, and then come off of it before they do.

        • HI ,

          I AM DOWN TO 150 EFFEXOR WITH A DRUG CALLED SEREQUEL I DID NOT SUFFER WITHDRAWAL, BUT SEREQUEL CAUSES A PERSON TO BE VERY SLEEPY AND WEIGHT GAIN. IF I AM GOING TO REDUCE TO O EFEXOE I WILL TAKE SEREQUEL AGAIN MAYBE FOR 3 WEEKS AND START SERTRALINE OR PROZAC TO KEEP DEPRESSION AWAY FOR A WHILE WHILE MY BRAIN AJUSTS , I DON,T WANT TO GET SUICIDE IDEATION.

          WHAT DO YOU THINK OF MY PLAN?

          REGARDS

          RACHEL COLLINS

  2. There have been several comments by email. This from James Moore who ran a very influential Let’s Talk Withdrawal podcast and who now has links to Mad in America.

    Thank you for sharing this all too familiar predicament. I don’t have enough experience to add anything particularly helpful, but I view this situation as essentially boiling down to one of two approaches. Neither will be easy and this poor person may have to come to terms with living a somewhat compromised life. Something I am personally struggling to accept myself.

    The first is to manage symptoms while maintaining on the Effexor at the lowest effective dosage, though whether this can be done for life is anyone’s guess. The second is an incredibly slow and gentle taper using a liquid form (if available). This also is a complete unknown. As this person has already been sensitised by a fairly rapid taper, any follow up taper needs to be agonisingly slow. Then, of course, there is the complication of the other drugs to address.

    The first objective in any treatment plan I would recommend is stabilisation before changes are attempted very slowly and gradually.

    I would be very interested in what the experts you have approached recommend and I hope this person manages to find a way forward that reduces their distress while also being something they can live with.

    With best wishes as always

    James

    • I have been on venlafaxine modified release for over 2 years 75 mg. I contacted my doctor about coming off it and she said as it was a modified release I could go to 37.5 mg for 2 weeks then stop completely. 1 week in I feel nauseous and tearful with long earful periods at night and fatigue in the day. Is this period of only 2 weeks too quick or I can you indeed come off the MR Venlafaxine this quickly?? Has anyone else got experience of coming off the MR Venlafaxine??

      • Two weeks in your case self-evidently is a lot too quick. Any kind of venlafaxine can be desperately difficult to get off.

        DH

      • Hi Marie
        I was on same 75mg pills from hell for only 2 months, if I had known what I do now….
        I reduced by tipping half down the sink for a week and a further week later here I am after stopping, forgotten what sleep 💤 is… even with 20mg tamazepan every night.
        Ringing in my ears brain zaps are easing, maybe I’ll eat soon! Praying this unbelievable evil comedown ends very soon, I wasn’t warned about this!
        This is not the way I would advise you to do it so please get some help of a pro.
        I wish you all the best.

  3. This comment is from Stevie Lewis who has played a big part in the raising the issues in Wales and in liaising with Marion Brown and colleagues in Scotland to present patient centred evidence to government and regulators.

    My heart sank when I read the story you sent through. How many times have we seen the same thing?

    “I was given an AD for a mild problem. I was on it a long time at various doses. Whilst on it or in withdrawal I developed deeply unpleasant symptoms no-one can explain. When I went to ‘an expert’ for help they gave me even more drugs and now I’m worse”. Sooooo predictable.

    I’ve just seen James’ reply to you and there’s not much for me to add. This poor woman wants to know what to do now, today, to feel better. My input is really an overview:

    – get all the chemicals out of your system slowly and steadily.

    – accept you are going to be ill for an indeterminate amount of time. I had to live with and through the terror, the phobias, the extreme jerking to get to the other side of it, there was no alternative.

    – believe your nervous system (and whatever other bodily systems have been compromised) will heal once it is left to its own devices, and most if not all mystery and/or unpleasant symptoms will go

    This means avoiding “taking” anything – most pleas for help usually are framed around “what can I take today to make me feel better” and the answer has to be – nothing.

    That’s your body. As for your mind, you have to learn to befriend the fear that you might never get better, as anyone with chronic illness does.

    This is a long game, which no-one wants to hear.

    Best wishes

    Stevie

    • It’s refreshing and your words drum up fear but also hope . My wife suffers from PTSD and Depression, and has been put on venlafaxine….on 300mg a day , hindsight we wish we had opted for alternative drug or treatment as she’s wanting to get off it , but reduction in dosage has its own evils…it seems like an awful drug .
      But she wants to try her best and is prepared for the worst, whatever that maybe.

  4. How important it is when withdrawing from a drug that the person drawing up the plan knows what they are doing. In so many cases the presenting person is not believed when they describe symptoms they have never had before. Then what happens is usually the signing off of other prescriptions and before you know it, the original drug is lost and confused amongst the mix.

    This situation can often times become extremely difficult to unravel.
    What started off as a withdrawal from one drug has now morphed and it will be almost impossible for someone to sort this out. Especially the initial prescribing doctor.

    This situation is unfortunately what most doctors do, not knowing enough about each drug and can land the patient in a perilous position with a very difficult way out.

    This patient’s life has become so miserable and become a much worse situation than it should be.

    A very long slow taper is ideal.
    If the patient becomes uncomfortable and distressed at various points, then they should revert to the previous level and stay on that for a month or two until they feel happy to reduce a tiny bit more.

    So many doctors have different ideas, but, if the patient is distressed, then clearly a plan needs to be drawn up which doesn’t involve random and often times reckless additional drugs, leaving everyone confused as to the right way forward.

    Reducing from 40 mg Paroxetine involved reducing with tablets and liquid over a year and even with this plan, a steely determination is necessary to ride through what can be months and even years of adjustments and most importantly, at this point, to try not to be cajoled, by the doctor, in to starting right back at the beginning or to take thoughtless additions, and this can be the hardest part of the merry-go-round of Complex Withdrawal.

    • I would add that, as simple as it may sound, trying to remain calm is also important. By this, I mean all who are concerned with the patient’s care. The person in withdrawal is obviously dealing with feelings and sensations that are overwhelming; having family or friends who can take things in their stride without an element of panic or bewilderment can be of great support to the sufferer. Having a ‘professional’ who is also calm and taking everything in his stride brings the whole situation together so that progress is possible.
      We saw the other side of matters too – a professional who was overwhelmed and failed to listen to family, created a raft of problems whereby the patient ( without a hint of getting support to withdraw) was ready to give up his life due to no hope of recovery.
      Thankfully, we were shown a better way. Not an ‘easy way’, just better!

  5. I wonder if getting in touch with someone who has found ways of dealing with pain would provide different ways of dealing with the immediate need of “something to make me feel better today”? I know of a young person (through Twitter) who has been quite successful in dealing with her own physical pain and mental anguish. Could ask permission to share her details if it would be useful. This would be together with all James and Stevie suggest of course.

  6. When I was prescribed more medicines and told to go through more futile procedures especially after I went to hell and back, I decided to turn by back on Western Medicine completely and I have never looked back.
    I knew that if I did not listen to my instincts, I would not be here writing on RXISK today.
    Victims of misdiagnosis, overmedication, life threatening procedures can go through unnecessary toxicity, cardiomyopathy, heart arrhythmia, coma, and sudden death.
    A lot of medicines and unnecessary procedures is similar to ‘A jab in the dark’ medicine and if you get severely harmed, no one cares! ~ You are on your own!

    The patient who is prescribed medication or unnecessary procedures, should understand without any ambiguity, the indications for use and the risks, side effects, adverse reactions and warnings associated with the medication(s) and procedures.
    Patients should not have to go on a witch hunt for information regarding what medicines they are prescribed. Even if they had the MIMS bible, I am sure that a lot of the information would not be in there!
    Patients should not feel guilty for questioning what they are being prescribed and Clinicians should inform their patients of all the rxisks regarding procedures not just a selected few. If patients are well informed they may be spared a lot of unnecessary suffering.
    If a health clinician fails to warn patients of all these things, they have failed in their ‘duty to care!’
    The family should be able to question all health care professionals because through the gathering of vital information patients and loved ones can make better informed decisions.
    The cure is worse than the disease and you should never give anyone consent to do anything to your beautiful body without knowing all the perilous implications.

    My heart goes out to so many people who have put all their faith and trust in the system, only to be duped many times over.
    This is so unethical and morally degrading to the human/animal species. When profits are more important than people, we have to question how did medicine become so delinquent and pervasive. CB

    “The market for truth is very small. Comfortis in great demand.” Harold Foster

  7. Simon ‘exploitative’ Wessely.

    Selling your grandmother for a song …

    Great Comments on this Blog …

    ‘Perhaps a study ought to be conducted into the number of times Sir Simon Wessely has been involved in positing some kind of psychiatric condition which avoids the British state from recognising medical damage or having to pay out benefits. A knighthood is small recompense for his services – he should be an Earl or a Duke.’

    To repeat what I wrote then, the powers that be (AF, SW etc) are scared silly of the people. Their reactions scream guilt. They scream that if we ever found out what they had done to us, we would rise up and they would be in trouble.  Just to be clear, I am not advocating anyone rise up, I am describing the body language of the Bishops and Cardinals of medicine.

    https://davidhealy.org/from-the-grassy-knoll/

    “No, Dr. Wessely, that’s not what it means”

    https://www.madinamerica.com/2016/03/psychiatry-bashing/

    Time for Wendy, Simon, Dinesh and others to Man Up? They can’t say this is news. Successive presidents of the British Psychiatric College have been told about this problem for over 20 years since Charles Medawar first wrote to them.  They are in great part personally responsible for ongoing injuries from disbelief to thousands, maybe hundreds of thousands of people.

    https://davidhealy.org/the-horrific-effects-of-not-being-believed/

    Great Comments on this Blog …

    • Oh, to be a fly-on-the-wall …

      Chapter 10

      Path to Publication

      Children of the Cure

      Simon Wessely
      @WesselyS

      Less than an hour left – your chance to put questions to @fgodlee and Howard Bauchner @JAMA_current – retractions, preprints, coverage, scandals, top papers, peer review, open access, future of journals …whatever. #rsmlive

      – retractions, preprints, coverage, scandals, top papers, peer review, open access, future of journals
      …whatever

      Restoring Study 329
      Missing Data, Lost Lives and Antidepressants

      It has become the most famous clinical trial ever,
      that has two publications in the academic literature –

      9 Rounds, with the BMJ
      …whatever..
      .

      • I have often wondered with Simon Wessely having so much power and influence within psychiatry, and with the Royal College of Psychiatry’s campaign to get more and more of us on antidepressants, how many cases of life ruining PSSD, protracted withdrawal where people suffer sometimes very badly for many years, and occasionally for decades, and deaths from SSRI’s via akathisia, Simon Wesseley is either directly, or indirectly responsible for.

        I genuinely believe if the truth was known, he is a man responsible for a lot of human suffering, including deaths, and that he likely has a lot of blood on his hands.

  8. Effexor
    After its acquisition of Wyeth, Pfizer assumed responsibility for Effexor liability including lawsuits filed due to medical injury. Pfizer has faced multiple lawsuits after Effexor was used during pregnancy and may have caused birth defects. The company may also have faced lawsuits for other side effects or medical injuries.
    Related Pages
    In 2007, Effexor’s manufacturer, Wyeth was given a warning by the U.S. Food and Drug Administration (FDA) regarding misleading advertising which had minimized the risks of Effexor and overstated the effectiveness. Wyeth was acquired by Pfizer in 2009 and now manufactures Effexor XR and similar medications

    Everyday HealthDrugsSSNRI AntidepressantsVenlafaxineReviews

    1918 people have reviewed this drug Here’s a few – the majority had an horrific experience on it –

    Posted 0 months ago (6/13/2020)
    Rated Venlafaxine for Generalized anxiety disorder (GAD)Report
    I have anxiety associated with advanced Parkinson’s Disease (stage 4). Along with the anxiety I also have pain from PD rigidity and dystonia. The side effects trying to get started on the drug are vicious. I experienced nausea, dizziness, insomnia, my tremors were worsened and headaches. This was at the 37.5 mg starting dose for the XR version of the drug – I can’t imagine what a higher dose would do. As a result of the PD I am down to 40 kg body weight – maybe someone twice my size could tolerate it. I definitely do not recommend this drug.

    Posted 1 months ago (6/4/2020)
    Rated Venlafaxine for AnxietyReport
    My GP prescribed this to me and it was my first antidepressant I’ve ever been on. I have no idea what she was thinking but she prescribed me 75mg to start. I didn’t think to say anything as I was naive and didn’t know much about them. Worst decision I’ve ever made. The nausea and diarrhea and also stomach cramps plus much more are horrific. Do not take this.

    Posted 1 months ago (5/31/2020)
    Rated Venlafaxine for DepressionReport
    Prescribed 37.5mg of Venlafaxine about 5/6 weeks ago. Quickly discovered I can’t take it during the day, as it makes me nauseous. So I started to take it at night which was working fine. Soon notice if I forgot a day, I’d end up in agony by 2pm the next day. Throbbing headache, stomach pains, extremely nauseous, diarrhoea, light headed.. All of which were so bad, I am left unable to stand up right or eat/drink. I have now decided that, as someone who is forgetful and may miss a day here & there, that this drug is NOT worth it. I’m currently bed bound due to not having my dose last night (ran out), and I’m calling it quits. I’ve tried more antidepressants than I can remember and I’m now at the point where I want to give up. The side effects aren’t worth it. The only drug I’ve ever had zero side effects from was Sertraline (200mg daily), and only stopped taking it as I found my overall mood wasn’t improving. I’m ending my journey with antidepressants after trying Venlafaxine. I can’t physically take it anymore. It’s ruining my physically & mental well-being.

    Posted 1 months ago (5/17/2020)
    Rated Venlafaxine for MigraineReport
    I had an intractable hemiplegic migraine which was drug resistant – responded in 12 hours to this drug after 4 months – amazing response

    Posted 1 months ago (5/15/2020)
    Rated Venlafaxine for Postpartum depressionReport
    The side effects are absolutely horrible if you are a little late taking your dose. Turns out that the “side effects” are withdrawal symptoms. Due to this I asked my doctor to come off of this drug. I have been being “zapped” (feels like I’m being electrocuted briefly) then immediately experience vertigo and a sharp headache until my next “zap” which can occur every few minutes until you take you next dose and it kicks in… I am gradually coming off but the withdrawal is more intense and frequent trying to come off of it. I would never recommend drug to anyone. Also I still had PP anxiety while on this drug so it didn’t help me much to begin with. Ask for an alternative if your doctor recommends this drug.

    Rated Venlafaxine for Chronic fatigue syndrome (CFS; CFIDS; M.E.Report (On same site – I don’t know if the group took off)
    all of those that have experienced VENLOR/ VENLAFAXlNE – need all negative reviews, please can you make contact: info@daniellashapiro.com we want to get a group going and this will help us all tremendously. Let’s get chatting. We could form a group on Facebook however want to start here to see response 🙂

  9. I help Admin a Facebook withdrawal group just for those tapering venlafaxine. We have 6,200 members, with a constant stream of people wanting to join. There are many others struggling in different ways with this medication, such as side effects etc, who we have to turn away due to lack of knowledge, manpower and time (40% of people are turned away!).

    What is described in this article is common. Long term use, often off label for pain and menopause symptoms. Fast tapers using the standard doses which fail in the vast majority of cases and if they don’t fail, they suffer withdrawal after stopping the medication rather than during the taper. Symptoms can be severe. Those we catch in time usually reinstate and taper much more slowly, and usually successfully (using the well documented 10% of the previous dose per month or what is comfortable for them). But even some cannot get of this medication due to the severity of the withdrawal symptoms, even tapering at 5% of the previous months dose or less.

    It is so disheartening to read an article like this where someone is subjected to a prescription cascade because of misdiagnosed withdrawal. This happens too much and must stop. Facebook groups take up so many of these cases. There are tens of thousands of people being helped to taper off various psychiatric medications, mainly ADs. Its a travesty.
    Ed White

    • John Read
      @ReadReadj

      Experts fear people will end up on antidepressants they don’t need https://dailymail.co.uk/health/article-8448487/Experts-fear-vast-numbers-people-end-antidepressants-dont-need.html?ito=amp_twitter_share-top… via
      @MailOnline

      John Read, a professor of clinical psychology at the University of East London, adds: ‘Being scared at the moment is normal. It is a social problem, not a mental health one. We fear we are about to see a big rise in prescribed medication. Already in the U.S., there has been a 30 per cent increase in drug prescriptions for depression and anxiety since the start of the coronavirus outbreak.’

      Tidal wave of mental woes? 

      Meanwhile, are we really about to suffer a ‘tsunami’ of depressive, anxious mental illnesses, as the Royal College of Psychiatrists sensationally predicts?

      ‘end up on prescription pills they don’t need (possibly causing crippling side-effects and withdrawal problems)’

      Will drug firms cash in on our Covid anxiety? Experts fear vast numbers of people will end up on antidepressants they don’t need

      https://www.dailymail.co.uk/health/article-8448487/Experts-fear-vast-numbers-people-end-antidepressants-dont-need.html

      By JOHN NAISH FOR THE DAILY MAIL
      PUBLISHED: 22:07, 22 June 2020 | UPDATED: 22:21, 22 June 2020

      As if the Covid-19 pandemic wasn’t enough, unprecedented numbers of people are suffering emotional fallout from isolation, money worries and fear of coronavirus infection, leaving Britain facing a tidal wave of anxiety and depression.

      That’s the stark warning from the Royal College of Psychiatrists, with the organisation’s president, Professor Wendy Burn, declaring: ‘Our fear is that lockdown is storing up problems which could lead to a tsunami of referrals.’

      The Royal College of Psychiatrists predicts that many of those affected will be people who have never before been diagnosed with depression or anxiety. 

      Dr Read said he found the paper’s intent ‘disturbing’.
      ‘We are already concerned about a further increase in unnecessary antidepressant prescribing during the pandemic,’ he says. 

      ‘The bizarre notion of using drugs to prevent depressive reactions happening could push prescribing rates through the roof. This is very worrying when we already have one in six adults taking antidepressants.

      ‘The paper also makes no mention of problems withdrawing from antidepressants.’

      Last October, Dr Read co-authored a review of evidence, in the journal Addictive Behaviors, which found that 56 per cent of those who attempt to come off antidepressants suffer withdrawal effects.

    • I have been on effexor xr 75 mg for almost a yr and felt about the same TBH. However , I had ran out and cldnt make it to my Dr to get a refill script. She stated to me an appt and by that time I had been out for approx 3 days. The next spot she had open was a week later and so I wld have been without my meds still. The withdrawal was almost immediate, as I tried to explain to her the headache was horrific. Anyway long story short , I basically was forced to quit alone , cold turkey. It has NOT been easy, and side effects are NOT something anyone wld wish for willingly I’m sure. , But I have managed to be without effexor for 13 days now and the worst I think may be over with the exception of the brain zaps, numbness in my lips and face, some short of breath at times, fatigue, and dizziness. I keep doing my daily routine and break when I just get to sick at my stomach and wanna puke, or the constant daily diarrhea makes me weak. It’s not easy, but I’m a tough gal so I’m gonna keep on doing my best. I get no slack time or much support during any sickness so this isn’t much diff at this stage in life. So saying that, just know, if ya wanna stop it, you HV to be willing to deal with all that comes with that choice. #staytoughenedup

  10. thebmj carries a massive advert for Spravato today -it was flagged up in Rxisk a while ago https://rxisk.org/assisted-dying-going-gentle-or-not-so-gentle/
    Venaflaxine /Effexor used in trials is referred to below with other ADs
    On another planet If medical journals are advertising dodgy meds they should be considered partly culpable for the harms being caused

    Janssen
    SPRAVATO® (esketamine)
    A breakthrough for
    your treatment-resistant
    Major Depressive Disorder patients1
    SPRAVATO® is the first licensed antidepressant (AD) in 30 years that offers a new mode of action,
    thought to target a glutamate receptor*2-7

    HOME
    SPRAVATO
    PRESCRIBING INFORMATION AND ADVERSE EVENTS REPORTING
    HOME PRODUCTS SPRAVATO® (ESKETAMINE)
    Primary efficacy results for change in MADRS total score for 4-week clinical trials (ANCOVA BOCF)2

    § Nasally administered SPRAVATO® or placebo nasal spray; oral AD = a newly initiated AD (SNRI: duloxetine, venlafaxine extended release; SSRI: escitalopram, sertraline).
    || Difference (SPRAVATO® + oral AD minus placebo nasal spray+ oral AD) in LS mean change from baseline.2
    ¶ Median unbiased estimate (i.e., weighted combination of the LS means of the difference from placebo nasal spray+ oral AD), and 95% flexible Cl.2
    # Treatment group that was statistically significantly superior to placebo nasal spray+ oral AD.2

    What else would you like to learn about SPRAVATO®?
    Please click on an icon to select a topic you are interested in:
    Visit the SPRAVATO® Toolkit
    For videos, guidance documents, and more, to help you get your patients started on SPRAVATO®
    Contact an Account Manager
    Want to know more? Our representatives are available to take you through how SPRAVATO® could help your patients break free from treatment-resistant MDD (Would be interesting if someone di contact them to go through it! could help patients in a way they don’t expect).

    Adverse events should be reported. (A cynical end note)
    This medicinal product is subject to additional monitoring and it is therefore important to report any suspected adverse events related to this medicinal product. Reporting forms and information can be found at http://www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. Adverse events should also be reported to Janssen-Cilag Limited on 01494 567447 or at dsafety@its.jnj.com.

    * Following the development and approval of the SSRI fluoxetine in 1987, approved treatments (including ‘atypical’ antidepressants such as mirtazapine, agomelatine, etc.) have either focused, or continued to have at least some effect on, the monoaminergic system.3–7

    ** As assessed by difference in MADRS total score, SPRAVATO® + oral AD demonstrated a 4.0 point superiority vs placebo nasal spray + oral AD at Day 28; p=0.02. 28.8

  11. There’s another wadge of warnings about Spravato on Johanna’s post Susanne

    https://rxisk.org/bait-and-switch-the-great-ketamine-breakthrough/

    “The scariest thing possible in a new-drug trial, I’ve heard some cynics say, is that people start dying – but the second scariest thing is that people start getting better.  Where’s your revenue stream then?  Spravato may do little or nothing for depressed people who have tried other treatments without success.  But as a guarantor of future profits, it may be just the “game changer” the drug companies have been yearning for.”

    Bait and Switch …

  12. It’s strange how the same person can sometimes experience both genital numbness and extreme itching.Two opposite extremes of sensation caused by the one drug.The reaction being to try sometimes extreme stimulation to activate the ‘deadened’ nerves and also seeking ways to deactivate the over active cause of itching. One cold ,one hot.

  13. I’ve been on Effexor Xr for over a year and a half now for PMDd. I have decided that I do not want to depend on this medication (even though it’s been helpful). The decision came when I missed a dose and became aware that the symptoms I was having were extreme! The dizziness, the headaches, and nausea was horrendous; and now any thought of missing a dose puts me in a panic. I have tried to be diligent on taking it every night as I do, but of course I am human and forget. I dont know what is worse this withdrawal feeling or the manic episodes i have with pmdd. Theres also gotta be other anti depressants that can help, until I find those I have decided to come off the Effexor xr with the guidance of my Dr. I was at 37.5 for a year and recently changed to 75mg, but now am back to 37.5 mg and I am feeling the worst symptoms.
    A history of my time on effexor also made me notice that my already disturbed sleep was even worse with effexor. I dont take any sleeping pills because that’s another thing I dont want to depend on. Anyway, other symptoms I’ve noticed is a brain fog, I definitely feel numb on the meds, at times I cannot compute a conversation, all I can hear is jibberish (like snoopy from the peanuts talk, is how I can explain it).
    Hopefully, I can flush this medication quickly and start a new form of antidepressant, or something more natural. If a medication makes you feel this bad when trying to come off it, it cannot be good.
    I’ve been taking omega 3s and a brain formula to help the tapering effect. Hopefully that eases the transition. Good luck to anyone on the same boat, it’s not pleasant hang in there!

  14. I can completely relate to the skin sensations you are experiencing from Effexor withdrawal. After finding out that my Effexor was most likely the cause of my extreme weight gain I decided (incredibly stupidly) to stop taking it. I tried to taper myself from it but I only had the 150 mg strength. My insurance had been terminated and I couldn’t get a tapering dose without an office visit. I tried to skip days between doses, gradually skipping longer periods until I could stop completely. I might as well have quit cold-turkey. The sleep deprivation is the worst symptom. I’ve tried all over the counter sleep aids but rarely sleep longer than an hour without waking up. I got brain zaps frequently during the first week. They feel almost as if my brain is cringing or tingling. The closest comparison I can think of is the sensation of your foot falling asleep except it only lasts for a second or so. My appetite completely vanished. I lost 3 pounds of pure fat within a week. I have had a constant dizzy/lightheaded/headache. It’s comparable to a bad sinus headache. My mood started as grumpy… I’d get irritated at the slightest thing. It then transitioned into emotional. Surprisingly I don’t feel depressed, but even the simplest song or tv commercial makes me cry. The worst symptom would be the skin tingling. I relate it to the Effexor withdrawal because the timing coincides perfectly and I’ve never experienced this before. It’s mainly at night. After sleeping for an hour I wake up to an itchy/tingling sensation, mainly in my feet but it eventually spreads throughout my body. It is a pins-and-needles feeling and feels like the itch exists below my skin. It is unbearable. I’ve tried anti-itch creams and lotions, Benadryl, warm baths… nothing relieves it. During the day it is dormant… almost as if it’s related to circulation or something resulting from lying prone. It is a very restless feeling. I find myself taking baths at two am and pacing my bedroom hoping for some kind of relief. I’ve found nothing relating it to the withdrawal until I stumbled across this post. I’m hoping the symptoms eventually subside. I was only on 150 mg/day for a year. if anyone reading this is thinking of stopping Effexor DO NOT STOP COLD-TURKEY! It’s not worth it. If you are considering beginning Effexor please explore all other options first. It is one of the hardest SSRIs to stop taking.

  15. Damn, that is a high dose! I’m so sorry for all your up and downs. In regards to something not necessarily being a common symptom, it doesn’t mean it couldn’t be a rare symptom that only appears in you and a few others. I’ve had that with multiple SRRI’s. I will say that I do feel like I have VERY DRY SKIN on the 75mg even though I’m moisturizing. I also experienced strange deep bruises on my legs which is another rare side effect.

    I’m on Effexor but only needed it for 8 months (postpartum anxiety) and went up to 75mg XR. I am not taking that every other day until I no longer feel withdrawal symptoms then going back to 37.5 and tapering off that slowly (every other day, then every 2 days, every 3…etc.) per my doctor.

    Only thing I get are headaches at night and like the feeling that my brain is trying to float out of my skull (similar to that feeling you get at the top of a roller coaster except instead of your stomach, in your head). I actually like that feeling so it isn’t a nuance beyond the fact that it lasts continuously. I ran two miles because the feeling is also like runners high and that helped. Eating well and drinking water, keeping in motion, all helps A LOT. I didn’t have any symptoms when I started beyond intense vision brightness the first week around the moment I took them. I’ve had similar things happen in my youth and it seems the higher the dose, the more I felt i was a teenager again which isn’t a good thing for me haha.

    Anywho, I hope it gets better for you.

  16. I too have the skin issues, but there is nothing there. No one seems to be taking me seriously. I didn’t even do cold turkey. Have been weaning from 75mgs for 2 months now and am finally at the end, but my w/d effects are getting worse. Complete insomnia, body aches, restless leg and the total body itching. I’m a psychotherapist with much person experience trying medications, staying on some for years and then coming off eventually. And it wasn’t ever easy, but it’s never been this hard. And I’ve been on Effexor before for 4 years and came off and it was ok. This time I was only on for a handful of months and I’m falling apart from the withdrawals. I don’t know what to do. I also have insurance issues right now and won’t be covered until a couple of months from now.

  17. I was on 75 mg of Effexor and then was put on 37.5 mg for one month and then would be off completely. I was not told that there would be side effects. Trintellix was increased from 10 mg to 20 mg. Which is a fairly new med for be. I am on 125 mg of Topamax. The Topamax and Effexor I have been almost completely migraine and pain free. Decreasing the Effexor Immediately brought back the pain between my shoulder blade. I am falling asleep continually during the day and I did see that narcolepsy can be a side effect of going off Effexor and extreme itchiness. I’m very surprised that I was not told about these side effects. The Trintillex and Effexor can cause serotonin syndrome. I think they should’ve just left me on Effexor and Topamax because not having pain has improved my life greatly and forget about the Trintellex.

  18. I’m so sorry to hear about what you’re going through. I’ve been to hell myself last year. I had to quit suddenly with a tricyclic antidepressant because of harmful side effects. My doctor thought it was ok, since I had the lowest dose. After six weeks of no withdrawal at all, I suddenly started to have strange muscle contractions. The ones you feel and see when you work out a lot. And then the dizziness and nausea started and the horrible brain zaps and over sensitivity for sound. I couldn’t function anymore. Nobody knew what was going on, I’ve seen by so many doctors and neurologists, run so many tests, but they couldn’t find anything. Then the parasthesia started. Nerve pain but also strange sensations on my skin. Crawling, burning, tickling, tingling, electric sensations. I had to start duloxetine to help me with it. When I got on Duloxetine my problems started to fade and after six months I was functioning normal again. De doctors still denied it had to do with withdrawal but by that time I was convinced it was withdrawal. I found out a pharmacy here in the Netherlands that offers tapering kits for heavy anti depressants (Regenboog apotheek). My doctor agreed for me to do it, and since April I started a very slow tapering schedule. I first had to switch from duloxetine to venlafexine. Even with the help of the slow tapering I’m still experiencing withdrawal, but it’s not as worse as what I experienced last year. Your skin issues might be parasthesia caused by a fast tapering. There’s not much knowledge about severe withdrawal symptoms. Every week I’m experiencing a new one. I had terrible bruises from venlafaxine, insomnia (I used strong melatonin tablets instead of sleeping pills), my period was extremely painful and lasted for two weeks, restless leg syndrome, sexual dysfunction, brain zaps (luckily not with the over sensitivity that paralyzed me last year), constipation, bloating, and many many more. Right now I’m experiencing some of the parasthesia. But due to the slow tapering I’m not experiencing them all at the same time and in full effect. I just can’t believe your doctor gave you such a high dose again and even added lyrica and all the other heavy stuff. If they only knew how to tapper off slowly….Try to find a pharmacy that offers tapering kit for anti depressant. I have my life back again, and I really, really hope you’ll get there one day too. Wishing you all the luck and good health.

  19. Hi, I’m starting Effexor xr , today is my second day, but after reading all these posts I’m really scared to continue this medication. Any thoughts? Should I stop and be on something else ?
    Thanks

    • Esme see if you can try something else first.
      I was on it 2 years & gradually tapered off.
      The side effects from stopping are not nice, I’m 5 days in & have stomach pain when I eat, diarrhoea, brain zaps & worse of all I hate going to bed as I seem to get really anxious & have trouble getting to sleep. I wasn’t warned about anything to do with withdrawal when I started it.
      Only positive is I’m losing weight I put on when I went on it. Good luck.

    • I’m going thru withdrawal now. W/out giving you my entire story with Effexor, the MOST IMPORTANT statement to you: DON’T CONTINUE! Effexor is THE HARDEST ONE TO WITHDRAW FROM! I’ve researched it very well. If you have to take a an antidepressant, DON’T TAKE EFFEXOR. AKA: Venlafexaline.

    • I started in June for mild depression, lack of motivation, 37.5 mg. A short time later I felt it wasn’t working & this happened twice so my dose was increased to 75 then again to 125mg. That did not go well, I was constantly tired, didn’t want to get out of bed in the morning, yawned all day & GI issues. Now I am tapering off & it’s no fun. Currently back down to 37.5 every other day and going thru withdrawal experiencing many of effects others have mentioned. I can’t wait to get this out of my system. I would not have taken it had I known what I know now.

  20. I had been on Effexor 75mg for 15 years and was given a plan to taper by my Psychiatrist and GP. I had ceased the Admantadine and Effexor within nearly 3 months which certainly wasn’t long enough. I have neuropathic pain and take Oxycontin and Oxynorm. It wasn’t long before my whole body was engulfed with pain. I lost nearly a stone within a week which is what I had put on but I looked annorexic. It has been over a year and I have suffered unbearable symptoms. Dry skin gave me dermatitis of the hands where my skin would blister if in contact with water. This lasted 4 months. I developed a tremor with my hands. I wasn’t sleeping. The nerves were firing in the back of my legs. I had really painful spasms in my lower back. I noticed I was then dealing with worse pain down one side of my body. Xrays revealed bursitis of the shoulder and a spur of my heel both being annoying. My shoulder will not heal. My GP claims he hasn’t seen any withdrawal symptoms like mine and even tried to increase my dose of Effexor. I had gone on 37.5mg just to see if my problems were helped but I was determined not to increase the dose. Nothing changed. I am now only taking one of six small tablets after opening the Effexor capsule. This antidepressant makes me so hot and people have commented on the heat from my body. I cannot cope with another summer so I need to be rid of this awful drug. In order to not lose weight it’s another low dose antidepressant which I despise taking. I know the neurons in my brain are damaged from all I have read as well as other awful things. I don’t have Parkinson’s Disease yet Amantadine helps with pain. I know all the drugs I take affect my brain.
    I hope anyone reading what I have written will think twice about taking Effexor or any antidepressant.
    I am just existing and hope I will improve over time. I try and think of happier times.

  21. Hello H,
    I am currently in the slow tapering process of Effexor XR from 187 mg down to 112mg (75 + 37.5). For Major depression and anxiety/panic/GAD, migraine and perimenopausal symptoms. Every 2-3 weeks (if feeling better from all withdrawal symptoms) I reduce by 37.5mg.
    Getting to the point…tramadol is a lot like effexor xr as they are both SNRI’S. In order to completely come off tramadol(brand name ultram). I tapered for months from 300 ER down to 50mg daily. Get an understanding doctor and maybe try what worked for me??
    Over one months time, I had the blessed crutch of small (quarter to halves) of Percocet 5 mg for all body pains and Ativan 1mg for muscle relaxing and calming ability and for sleep. Also, Bonine or Zofran and Seabands for nausea, vomiting and dizziness. Ate lots of saltines and drank tons of water to flush out toxins. Simple and bland diet. I had one month off of work and it was totally manageable and I will not take that drug again. For now, ill stick with lower dose of effexor bc it helps. Ativan (lorazepam) for sleep and anxiety. Keep up daily light outdoor exercise if possible.
    As far as the red dots go, look carefully at your strong constipation medicine. I was once given a prescription strength Medicine for constipation and the ingredients were similar to those used to clean a car engine!! Made me sick and gave me migraine and terrible stomach pain. Chances are those chemicals could cause rashes of all kinds. Try adding 2-3 chewable Vitamin C gummies and double your water intake. Hoping you heal up quickly…these are just suggestions…im not a medical expert…just trying to offer ideas to H who is suffering. Warmest regards, Angel

  22. I am going through an accidental withdrawal as I changed doctors and he is requiring more visits to keep the meds. I missed making an appointment. It’s the weekend, day three of no Effexor (150 mgs). I have the same feeling of dry skin with my hands and generally a feeling of poor circulation in my hands and feet, which I believe is the cause of the discomfort, along with the brain zaps. I’m seriously considering continuing to work through this. I don’t like feeling like a drug addict, either. I also don’t like being dependent on a dismissive drug dealer (psychiatrist) for relief. My mood is ok at this point.

  23. Like I thought that doctors were not suppose to make you sick. I took effexor for 5 years ans i still have some issues and that was along long long time ago. I think i know what they made that effexor stuff from and it is a poison. We all got fooled.

    it was a huge money maker billions and billions of dollars.

  24. ok so the antidote for effexor may be small small amounts of fruit wine when needed.
    I used this several times. You will never get this in a hospital sort of place. but it did work. They the beloved doctor slammed me with depakote and resipdol after my er trip to one hospital i was then place in this other place and really slammed with some horrible pills which caused me to drool for like 2 days and i could not talk in this (hospital). There is a game here and it can only be played here near where i am.

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