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March 1, 2022 | 5 Comments


  1. Intrigued by the description resembling PSSD, I looked for updates on the first story (25F). She also talks about changes in her menstrual cycle caused by the vaccine, which is a possible side effect already noted and discussed by the EMA as well.

    I report some of her updates regarding sexual function (the first in this post is from October 15, 2021).

    November 7, 2021:
    – I’ve had significant loss of libido after 2nd dose, did anyone experience the same? And if it has improved or normalised how long did it take? Is there anything I can do in the meantime to speed up the improvements?

    – Maybe, it only started after my second dose which was in august. I lost a lot of sensation in the saddle area in general even not having the urge/sensation for needing to urinate but that has started to return 2-3 months in. Not started any other medications. I’ve had my hormones checked and they’re apparently fine however I don’t know what they were like before vaccination. I don’t think it’s related to physiological or emotional changes as that’s never affected it. I’m thinking it’s something to do with inflammation harming nerves maybe, I need to get my GP to look into it more.

    – It’s something to look into. I’ve never had issues with my libido at all ever. Definitely going to do something about it, it’s not what I need I’m a healthy 25F with no underlying comorbidities whatsoever.

    – I seen the doc a while back they’ve ruled out cauda equina syndrome. I’m thinking it could either be peripheral neuropathy, endothelial dysfunction or Guillane Barre Syndrome.

    Finally, privately, she briefly informed me that she is having improvement:

    February 19, 2022:
    “Libido started to slowly return 5 months after 2nd dose. I’m 6 months out now. It has improved but not quite where I need it to be yet”.

    March 1, 2022:
    “things have improved a lot”.

  2. Two PSSD topic opened by a guy on Reddit are having good visibility

    The first one was closed after a few hours by the moderators (i.e. it is no longer visible in the main page of the subreddit but still online and commentable). Now 465 comments and 1100 likes: https://www.reddit.com/r/todayilearned/comments/t3ewb7/til_antidepressants_can_cause_enduring_sexual_and/

    The second one after one day has got 360 comments and over 5800 likes: https://www.reddit.com/r/YouShouldKnow/comments/t6erjn/ysk_antidepressants_can_cause_enduring_sexual_and/

  3. A recent article on MedPage today noted by Jean Rees.

    No one knows for sure why COVID-19 is linked to male sexual woes, but growing evidence, including a new study in monkeys, has suggested that the SARS-CoV-2 virus directly infects the male reproductive system — just like other viruses such as mumps and Zika.

    Thomas J. Hope, PhD, a cell biologist at Northwestern University in Chicago, who co-authored the monkey study published as a preprint on bioRxiv, told MedPage Today that his team saw “the same pathology [in monkeys] that we’ve seen recorded in human studies. To an extent, we feel comfortable in saying it’s probably direct infection that’s causing all these problems.”

    Hope and co-authors hadn’t intended to break ground on COVID-19 and male sexual health research. They launched their study in rhesus macaques inoculated with the virus to determine if a scanning technology known as immunoPET, which is used in cancer and simian immunodeficiency virus research, could detect signs of SARS-CoV-2.

    They used an intravenously injected probe to light up areas that showed signs of infection and conducted PET/CT scans at necropsy to take a closer look. This strategy works because it points the researcher toward elusive antibodies that are akin to needles in haystacks, Hope said.

    “If we just take random samples, we can’t learn anything. But if I can make the needle glow, I can grab a handful of hay, hold it up, and open my hand to see if I captured the needle. If not, then I go grab another handful. Through this kind of approach, I can find a tiny little piece of tissue,” he explained.

    The technology worked, but not in the way that the researchers anticipated. Unexpectedly, they didn’t find much infection in the lungs, but they did discover a “robust and dynamic signal” of infection in the penises, testicles, and prostates of all three monkeys examined.

    These findings suggest that COVID-linked erectile dysfunction, swollen testicles, and semen dysfunction in humans are “likely a consequence of the direct viral infection of the tissues” in the male reproductive tract, they wrote.

    Hope said that this study confirms previous research that has found signs of the virus in the male reproductive system. At least two studies, published in 2020 and 2022, have suggested COVID-19 lurks in the testicles.

    As a whole, the findings challenge the idea that the male sexual problems linked to COVID-19 could be caused solely by systemic inflammation or symptoms such as fever. “This is all valuable information because we know so little right now, and this virus is hard to follow,” Hope said. “Once we know where the virus is in the body, we can use the appropriate therapy that will get to that spot.”

    Why study the virus in the male reproductive system of monkeys instead of humans? “We can’t get access to these tissues except for cadavers,” Hope explained. In vivo tissues are ideal, he added, but men are unlikely to agree to allow a researcher to poke around their privates for research purposes.

    Research like this in animals also offers a benefit because scientists can better track how long it takes for cells to become infected with COVID-19, Hope noted. In human cadavers, “the pathology associated with a specific organ could have happened 6 months ago, or 6 weeks ago. It’s variable.”

    T. Mike Hsieh, MD, a urologist at the University of California San Diego, told MedPage Today that it will be helpful to understand whether COVID-19 causes male sexual problems via direct infection of reproductive organs or by some other route such as systemic inflammation.

    He pointed out that other viruses — most famously, mumps — can target the testicles. An estimated one-third of adult men who get mumps develop swollen testicles, and their sperm count may also drop. More rarely, women can develop swollen ovaries.

    Hsieh said that while he has seen cases of erectile dysfunction in patients after COVID-19, “I haven’t seen any convincing long-term, chronic sexual problems from COVID-19.”

    What’s next on the research front? While funding is running out, Hope said that his team expects to explore the effects of COVID-19 on the female reproductive system. “I’m optimistic that by the end of the spring, we’ll have multiple female animals that will provide us insights into what’s happening in women,” he added.

    Previous research has linked COVID-19 in women to ovarian injury and higher rates of preterm births, ICU admission during pregnancy, and maternal deaths.

    Randy Dotinga is a freelance medical and science journalist based in San Diego.

  4. Could you please post the document containing the information from Reddit? The current link is broken. If you also have the original URL, that might also be helpful.

  5. It has been over a year now since my 1st and 2nd Pfizer vaccination which was in July and Aug 2021. I experienced major fatigue and a total loss of libido. Initially, I thought I was having a burnout from work. Months passed even through periods when I was working out and having a long break. My libido did not return as what it was before. In fact even after a year, it remains to be a mystery of where it has disappeared to. I’m aware there aren’t many studies of the vaccine on women and I hope more women can report more on their side effects. I am a healthy 44 F. I have no prior health conditions as well.

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