“Do you think studying monolayers of cells will tell you why you fall in love with a girl?" The quote comes from Rudolf Hess, who won the Nobel Prize for physiology in 1949. His students remembered him as telling them never to study a neurotransmitter or even a cell without thinking about where this bit of the body comes from and what it is supposed to do. This is one of … [Read more...] about Sex, Withdrawal and Boundaries
Sex
What’s Sex Got to Do with It
This post gives the text of an article that has just been published online in the Journal of the Royal Society of Medicine - see Here. Another version of the material is in video form - Antidepressants and Sex: a Strange Story. Background In June 2019, in response to a petition, the European Medicines Agency (EMA) asked pharmaceutical companies to warn that sexual … [Read more...] about What’s Sex Got to Do with It
Everything’s in Hand: Isotretinoin and the Usual Guff
Niks aan de Hand - Nothing out of hand. This item has just appeared in the BMJ: An expert group has been reconvened to review recent safety data relating to the acne drug isotretinoin (Roaccutane) and evaluate the risk of sexual and psychiatric adverse effects, including suicide. The Medicines and Healthcare Products Regulatory Agency’s isotretinoin expert working group … [Read more...] about Everything’s in Hand: Isotretinoin and the Usual Guff
Not the RxISK Manifesto
Last week's RxISK Manifesto post featured an article then just published in BMJ. The BMJ picture that went with the article looked like this. This gives entirely the opposite message to the article. The article says a doctors job would be a lot more interesting if they listened and encouraged anyone consulting them to become researchers rather than problems. It also … [Read more...] about Not the RxISK Manifesto
RxISK Manifesto
This post is close to identical to an article that has just appeared in the BMJ - Clinical Judgments, not Algorithms, are key to Patient Safety. Immediately on taking a selective serotonin reuptake inhibitor (SSRI), most people have some genital anaesthesia.1 This may be aggravated on withdrawal of the drug and can remain for years after treatment has stopped, constituting … [Read more...] about RxISK Manifesto
PSSD Patient Experiences
New paper "If you wish to have such “syndrome” continue what you are doing ... read obscure studies and reviews in obscure databases and I can guarantee to you that you will have it till the end of your life!" Anyone who has experienced a serious side effect from a medication will know how difficult the conversation with your doctor can be. In our new paper, “Post-SSRI … [Read more...] about PSSD Patient Experiences
Business Opportunity courtesy of Impeto Medical
Some months ago we had organised for 6 volunteers with PSSD to get tested for peripheral neuropathy, using a Sudoscan, made by Impeto Medical, who are based in Paris. By chance we found that there is a genital adaptor for the Sudoscan that has been in use for several years in Paris, leading to a publication over two years ago. Through a colleague, we got in contact with Dr … [Read more...] about Business Opportunity courtesy of Impeto Medical
Device Wrecks & Regulators?
RxISK is powered by people working behind the scenes - picking at threads and sometimes finding something rather different to what they expected. One of those who can't resist a loose thread is Suzanne Stevens, who has been interested in our Sudoscan problem. Many of you suffering with PSSD or related PRS, PRSD and PGAD conditions have been emailing Impeto Medical in Paris … [Read more...] about Device Wrecks & Regulators?
Sudoscan Saga & Propecia/Finasteride Survey
Sudoscan Several months ago, we became aware of a device called Sudoscan made by Impeto Medical, based in Paris. It’s mainly used to assess peripheral neuropathy in the hands and feet. But the company also have a special adaptor for Sudoscan that has been used to test genital function and found disturbances where other tests haven't. This is custom-made and isn’t commercially … [Read more...] about Sudoscan Saga & Propecia/Finasteride Survey
Cis- and Trans-Drug Wrecks
After a Montelukast Withdrawal Syndrome post two weeks back, we had more comments than after any previous post - so much so that this seemed worth noting in a Post in its own right. After last weeks Transgender Meds, we have had fewer comments than after any previous post. This also seems worth noting in the form of a post. This is not so much a post as a series of notes … [Read more...] about Cis- and Trans-Drug Wrecks