A 2016 RxISK post discussing how common post-ssri sexual dysfunction (PSSD) might be, highlighted Colpi et al., 1991, and Yilmaz et al., 1999 showing fluoxetine and clomipramine, both serotonin reuptake inhibitors, reduce genital sensation. These studies feature in our 2018 paper: Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and … [Read more...] about New Test to Confirm a PSSD Diagnosis
Sex
Withdrawal, PSSD and Cholinergic Drugs
Health Warning I don’t know a great deal about the issues in this post. Experts by Experience and The Marketing of Anticholinergic Maleficence along with Psychotropic Drug Follies will give some feel for the background that makes it difficult to be certain about anything linked to the cholinergic drugs. The Past Present and Future article will need to be downloaded to take to … [Read more...] about Withdrawal, PSSD and Cholinergic Drugs
Experts by Experience and Nobel Prizes
In the mid-1980s, I gave a very nice man, an in-patient, weekend leave. He hung himself. Everyone was shocked. The drug I’d put him on was the trigger to his suicide. Soon after, a medical resident called me to a case she was handling. She seemed exceptionally impressive, so I was surprised to hear afterwards she was taking an antidepressant. She told me about the … [Read more...] about Experts by Experience and Nobel Prizes
What Counts? A Tale of Good and Evil
This title plays on words. Counting suggests numbers but also hints at values. This talk hinges on a clash between a worldview centred on numbers and one centred on values. The slides and text are below. A video record of the talk is here - What Counts? Slide 2: One of these two is on an antidepressant and unable to make love. Like drug induced Homicide, … [Read more...] about What Counts? A Tale of Good and Evil
How the Safety of Drugs was Destroyed
Emer Cooke, the CEO of the European Medicines Agency (EMA) is Irish. This is Dublin's famous Halfpenny Bridge which for some reason features in an article outlining the history of the phrase Tail wags Dog which seems appropriate for what followed. I wrote to Emer recently about a bizarre letter I received from Kinapse - A Brush with EMA - who run EMA's medical literature … [Read more...] about How the Safety of Drugs was Destroyed
The Wild Doctor – Le Médecin Sauvage
The French playwright Moliere loved poking fun at pomposity especially when it involved doctors. In Le Bourgeois Gentilhomme, he pokes fun at Monsieur Jourdain, a pompous upstart, who has come into money and is taking on airs and graces. Translating gentilhomme into gentleman misses what the word meant around 1660, which was more like civilized, the manners which … [Read more...] about The Wild Doctor – Le Médecin Sauvage
The Long Awaited PSSD Research Breakthrough?
This image is from an extraordinary blog which tells you how to sex your mouse Breakthrough? Most of the good ideas that RxISK has featured linked to the enduring sexual dysfunctions, whether PSSD, PRSD, PFS and PGAD, and in terms of other problems, have come from readers of these posts. Several readers have stood out in terms of contributions and this post comes from one of … [Read more...] about The Long Awaited PSSD Research Breakthrough?
Could Journalists be Doctors in Disguise
I had to give some workshops a few years ago to media students and either while thinking about what to say or in the middle of saying it, or soon after, it hit me that good doctoring has a lot in common with good journalism. Both hinge on getting the story right and key to that is having a real person whom others can contact to check out the story they have been told about … [Read more...] about Could Journalists be Doctors in Disguise
International Society of Sexual Medicine
This weeks post was supposed to be just about Sexual Mysteries. What's in a Touch? As it was waiting to be posted, a controversy blew up about the International Society of Sexual Medicine and claims by Dr Anita Clayton that there is no such thing as PSSD. There did not seem to be enough for a post in its own right but equally it seemed to make sense to say something and … [Read more...] about International Society of Sexual Medicine
Sexual Mysteries. What is in a Touch?
This is an important post for anyone hunting for a test for PSSD. If the CT fibres mentioned here are not fibres that show up distinctly on either skin biopsy or CCM, then these tests may not pick up a very real problem. We need some research on whether CT fibres show around the ankle or in the cornea. The slide above is from a fascinating lecture on Affective Touch by Francis … [Read more...] about Sexual Mysteries. What is in a Touch?